1Division of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology, Duke University School of Medicine, Durham, NC, USA.
Reprod Sci. 2013 Dec;20(12):1471-7. doi: 10.1177/1933719113488446. Epub 2013 May 7.
Obese pregnant women have higher rates of dysfunctional labor patterns, need for oxytocin augmentation, labor induction, postdates pregnancy, and cesarean delivery compared to normal weight pregnant women. We tested the hypothesis that myometrial oxytocin receptor (OXTR) gene and protein expression are affected by obesity in pregnancy. Myometrial samples were obtained at the time of cesarean delivery from the upper aspect of the uterine hysterotomy incision and processed for real-time quantitative polymerase chain reaction and Western blot. There were 63 myometrial samples available for analysis. The median body mass index (BMI) at delivery was 31.0 kg/m(2) (interquartile range, 26.0, 40.0 kg/m(2)), and the median gestational age at delivery was 38.0 weeks (interquartile range, 33.0, 39.1 weeks). The OXTR gene expression did not correlate with maternal BMI at delivery by linear regression, and the median OXTR gene expression did not differ between women with a BMI ≤ 30 kg/m(2) and those with a BMI ≥ 40 kg/m(2). The OXTR protein expression was also not affected by maternal BMI. Myometrial OXTR gene expression appears to be independent of BMI at the time of delivery. Dysfunctional labor patterns and increased oxytocin utilization seen in obese women may not be due to differences in OXTR expression, though functional studies are required.
肥胖孕妇在分娩时出现宫缩乏力、需要催产素辅助、引产、过期妊娠和剖宫产的比例高于正常体重孕妇。我们假设肥胖会影响妊娠时的子宫催产素受体（OXTR）基因和蛋白表达，并对此进行了测试。通过剖宫产术在子宫横切口的上方获取子宫肌层样本，进行实时定量聚合酶链反应和 Western blot 分析。共分析了 63 例子宫肌层样本。分娩时的中位数体重指数（BMI）为 31.0 kg/m²（四分位间距，26.0，40.0 kg/m²），分娩时的中位数孕龄为 38.0 周（四分位间距，33.0，39.1 周）。线性回归分析显示，OXTR 基因表达与分娩时的母体 BMI 无关，BMI≤30 kg/m²和 BMI≥40 kg/m²的妇女之间的 OXTR 基因表达中位数没有差异。OXTR 蛋白表达也不受母体 BMI 的影响。分娩时子宫 OXTR 基因表达似乎独立于 BMI。肥胖女性中出现的宫缩乏力和催产素利用增加的现象可能并非由于 OXTR 表达的差异所致，但需要进行功能研究。
