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孕产妇“单纯性”肥胖与产科并发症

Maternal "isolated" obesity and obstetric complications.

作者信息

Gilead Rami, Yaniv Salem Shimrit, Sergienko Ruslan, Sheiner Eyal

机构信息

Department of Obstetrics and Gynecology, Soroka University Medical Center, Ben-Gurion University of the Negev, Faculty of Health Sciences, Beer-Sheva, Israel.

出版信息

J Matern Fetal Neonatal Med. 2012 Dec;25(12):2579-82. doi: 10.3109/14767058.2012.716464. Epub 2012 Aug 28.

Abstract

OBJECTIVE

To investigate pregnancy outcomes, particularly cesarean delivery (CD), among women with "isolated" obesity (i.e. without additional comorbidities).

STUDY DESIGN

We conducted a retrospective population-based study between the years 1988-2010. The pregnancy outcomes of obese (prepregnancy BMI ≥30 kg/m(2)) and nonobese patients were compared. Patients with chronic hypertension, pregestational diabetes mellitus, other preexisting chronic morbidities, multiple gestations, age above 40 years, grand multiparity (above 5 deliveries), lack of prenatal care, and following fertility treatments were excluded from the analysis. Stratified analyses, using multiple logistic regression models, were performed to control for confounders.

RESULTS

During the study period, a total of 173,628 deliveries met the inclusion criteria; 1605 (0.9%) occurred in patients with "isolated" obesity. Higher rates of CD were found among patients with "isolated" obesity (30.7% vs. 12.3%; odds ration [OR] = 3.2; p < 0.001). When controlling for possible confounders, using a multivariable model with CD as the outcome variable, the association between "isolated" obesity and CD remained significant (adjusted OR = 2.6; p < 0.001). No significant differences were found in the risks of perinatal complications including perinatal mortality, shoulder dystocia, congenital malformations, and low 5-min Apgar score.

CONCLUSION

"Isolated" obesity, although not a risk factor for adverse perinatal outcomes, is an independent risk factor for CD.

摘要

目的

研究“单纯性”肥胖(即无其他合并症)女性的妊娠结局,尤其是剖宫产情况。

研究设计

我们在1988年至2010年间进行了一项基于人群的回顾性研究。比较了肥胖(孕前体重指数≥30 kg/m²)和非肥胖患者的妊娠结局。分析排除了患有慢性高血压、孕前糖尿病、其他已存在的慢性疾病、多胎妊娠、年龄超过40岁、多产(分娩5次以上)、缺乏产前检查以及接受过生育治疗的患者。采用多因素逻辑回归模型进行分层分析以控制混杂因素。

结果

在研究期间,共有173,628例分娩符合纳入标准;其中1605例(0.9%)发生在“单纯性”肥胖患者中。“单纯性”肥胖患者的剖宫产率更高(30.7%对12.3%;优势比[OR]=3.2;p<0.001)。以剖宫产作为结局变量,使用多变量模型控制可能的混杂因素后,“单纯性”肥胖与剖宫产之间的关联仍然显著(校正OR=2.6;p<0.001)。在围产期并发症风险方面,包括围产期死亡率、肩难产、先天性畸形和5分钟阿氏评分低等,未发现显著差异。

结论

“单纯性”肥胖虽然不是不良围产期结局的危险因素,但却是剖宫产的独立危险因素。

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