血小板功能检测的最新技术进展。
State of the art in platelet function testing.
机构信息
Department of Anesthesiology, Intensive Care and Pain Medicine, Experimental and Clinical Hemostasis, University of Münster, Germany.
出版信息
Transfus Med Hemother. 2013 Apr;40(2):73-86. doi: 10.1159/000350469. Epub 2013 Mar 18.
Platelets perform many functions in hemostasis but also in other areas of physiology and pathology. Therefore, it is obvious that many different function tests have been developed, each one conceived and standardized for a special purpose. This review will summarize the different fields in which platelet function testing is currently in use; diagnostics of patients with bleeding disorders, monitoring patients' response to anti-platelet therapy, monitoring in transfusion medicine (blood donors, platelet concentrates, and after transfusion), and monitoring in perioperative medicine to predict bleeding tendency. The second part of the review outlines different methods for platelet function testing, spanning bleeding time, and platelet counting as well as determining platelet adhesion, platelet secretion, platelet aggregation, platelet morphology, platelet signal transduction, platelet procoagulant activity, platelet apoptosis, platelet proteomics, and molecular biology.
血小板在止血中发挥着许多作用，但也在其他生理和病理领域发挥着作用。因此，显然已经开发出许多不同的功能测试，每一种测试都是为了特殊的目的而设计和标准化的。这篇综述将总结血小板功能测试目前在哪些领域得到应用：出血性疾病患者的诊断、监测患者对抗血小板治疗的反应、输血医学中的监测（献血者、血小板浓缩物和输血后）以及围手术期医学中的监测，以预测出血倾向。综述的第二部分概述了血小板功能测试的不同方法，涵盖了出血时间和血小板计数以及测定血小板黏附、血小板分泌、血小板聚集、血小板形态、血小板信号转导、血小板促凝活性、血小板凋亡、血小板蛋白质组学和分子生物学。
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