BRAF V600E阴性毛细胞白血病
BRAF V600E-Negative Hairy Cell Leukaemia.
作者信息
Langabeer Stephen E, O'Brien David, McElligott Anthony M, Lavin Michelle, Browne Paul V
机构信息
Cancer Molecular Diagnostics, Central Pathology Laboratory, St. James's Hospital, Dublin 8, Ireland.
出版信息
Case Rep Hematol. 2013;2013:513049. doi: 10.1155/2013/513049. Epub 2013 Apr 9.
Since the initial report of the BRAF V600E mutation in hairy cell leukemia, numerous investigators have demonstrated the presence of this activating mutation in nearly all cases of this disease. A case of hairy cell leukemia is documented with a classical clinical, morphological, immunophenotypic, and cytochemical profile in which the BRAF V600E was not detected. The diagnostic and therapeutic implications are discussed.
自毛细胞白血病中BRAF V600E突变的首次报告以来，众多研究人员已证实在几乎所有该疾病病例中都存在这种激活突变。本文记录了一例具有典型临床、形态学、免疫表型和细胞化学特征的毛细胞白血病病例，其中未检测到BRAF V600E。文中讨论了其诊断和治疗意义。
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