Mitsogianni Maria, Mitsimponas Nikolaos, Crespo Felipe, Hartmann Karl Axel, Klosterhalfen Bernd, Haase Sabine, Giagounidis Aristoteles
Klinik für Onkologie, Hämatologie und Palliativmedizin, Marien Hospital Düsseldorf, Düsseldorf, Germany.
Klinik für Strahlentherapie, Marien Hospital Düsseldorf, Düsseldorf, Germany.
Case Rep Oncol. 2018 Feb 14;11(1):109-113. doi: 10.1159/000486640. eCollection 2018 Jan-Apr.
The BRAF-V600E mutation has been established as a signature alteration occurring almost universally in hairy cell leukemia. Moreover, it can be detected in a small percentage of patients with non-small cell lung cancer. We report the case of a patient with a metastatic BRAF-V600E-mutated lung adenocarcinoma suffering from concomitant hairy cell leukemia. The identification of an identical BRAF mutation in both malignancies raises physiopathological considerations and might offer unique therapeutic strategies for this group of patients.
BRAF-V600E突变已被确认为几乎普遍存在于毛细胞白血病中的一种标志性改变。此外，在一小部分非小细胞肺癌患者中也能检测到该突变。我们报告了一例患有转移性BRAF-V600E突变型肺腺癌并伴有毛细胞白血病的患者。在这两种恶性肿瘤中均鉴定出相同的BRAF突变，这引发了生理病理学方面的思考，并可能为这类患者提供独特的治疗策略。
