Premkumar Sumana, Dedeepiya Vidyasagar Devaprasad, Terunuma Hiroshi, Senthilkumar Rajappa, Srinivasan Thangavelu, Reena Helen C, Preethy Senthilkumar, Abraham Samuel J K
Chennai Meenakshi Multispeciality Hospital Limited, New No. 72, Old No. 148, Luz Church Road, Mylapore, Chennai 600 004, India ; Dr. Kamakshi Memorial Hospital, 1 Radial Road, Pallikaranai, Chennai 600100, India.
Case Rep Oncol Med. 2013;2013:903094. doi: 10.1155/2013/903094. Epub 2013 Apr 7.
Radiotherapy is the primary form of treatment in patients with locally advanced cervical carcinoma. However for residual disease in the form of the persistent lymph nodes, surgery or chemotherapy is recommended. As surgery is not acceptable by every patient and chemotherapy has associated side effects, we hereby report the positive outcome of in vitro expanded natural killer cell and activated T lymphocyte based autologous immune enhancement therapy (AIET) for the residual lymphadenopathy in a patient with locally advanced cervical cancer after radiation. After six transfusions of AIET, there was complete resolution of residual lymph nodes and there was no evidence of local lesion. The patient also reported improvement in quality of life. As AIET has been reported as the least toxic among the available therapies for cancer, combining AIET with conventional forms of therapy in similar patients might not only improve the outcome but may also help the patients achieve a good quality of life.
放射治疗是局部晚期宫颈癌患者的主要治疗方式。然而，对于以持续性淋巴结形式存在的残留病灶，建议采用手术或化疗。由于并非每个患者都能接受手术，且化疗存在相关副作用，我们在此报告基于体外扩增自然杀伤细胞和活化T淋巴细胞的自体免疫增强疗法（AIET）对一名局部晚期宫颈癌患者放疗后残留淋巴结病的积极疗效。经过6次AIET输注后，残留淋巴结完全消退，且无局部病灶迹象。患者还报告生活质量有所改善。由于在现有的癌症治疗方法中，AIET被报道毒性最小，在类似患者中将AIET与传统治疗方法相结合，不仅可能改善治疗效果，还可能帮助患者获得良好的生活质量。
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