Department of Allergy, Hospital Lucus Augusti, Lugo, Spain.
J Investig Allergol Clin Immunol. 2013;23(1):30-6.
Increased tryptase concentrations are a risk marker for the severity of reactions to Hymenoptera stings or venom immunotherapy
To investigate serum tryptase concentrations in beekeepers with and without Hymenoptera venom allergy (HVA).
Serum tryptase concentrations were measured in adult patients with HVA (n = 91, 37 of whom were beekeepers), beekeepers without HVA (n = 152), and control individuals from the general adult population (n = 246).
Multivariate analyses revealed that serum tryptase levels were positively associated with beekeeping activities (P < .001) and HVA (P < .001). Tryptase levels were also positively associated with age (P < .001) and male'sex (P = .02), and negatively associated with alcoho consumption (P = .002).
Beekeeping and HVA are independently associated with increased concentrations of serum tryptase.
血清类胰蛋白酶浓度升高是蜂蜇或毒液免疫治疗后反应严重程度的风险标志物。
研究有无蜂类毒液过敏（HVA）的养蜂者的血清类胰蛋白酶浓度。
测量了 91 例 HVA 成年患者（其中 37 例为养蜂者）、152 例无 HVA 的养蜂者和 246 例普通成年人群对照个体的血清类胰蛋白酶浓度。
多变量分析显示，血清类胰蛋白酶水平与养蜂活动呈正相关（P<0.001），与 HVA 呈正相关（P<0.001）。类胰蛋白酶水平也与年龄（P<0.001）和男性的“性别”（P=0.02）呈正相关，与酒精摄入呈负相关（P=0.002）。
养蜂和 HVA 与血清类胰蛋白酶浓度升高独立相关。
