给予氟哌啶醇的下丘脑损伤大鼠模仿了给予氟哌啶醇加吗啡的正常大鼠的行为。
Hypothalamic lesioned rats given haloperidol mimic the behavior of intact rats given haloperidol plus morphine.
作者信息
de la Cruz F
机构信息
Department of Physiology, National School of Biological Sciences, National Polytechnic Institute, Mexico.
出版信息
Int J Psychophysiol. 1990 Jul;9(1):97-103. doi: 10.1016/0167-8760(90)90011-2.
Lateral hypothalamic (LH) damage produces rats which exhibit sensory neglect, somnolence and akinesia, while ventromedial hypothalamic (VMH) damage produces rats which exhibit sensory hyperesponsiveness (Marshall and Teitelbaum, 1977). Rats with large lesions of both LH and VMH are somnolent and akinetic but hyperesponsive to touch. When given haloperidol (5 mg/kg) the LH-VMH-damaged rats adopt an actively maintained splayed out posture, in which the limbs are abducted and extended and the body lies flat on the ground. While in this posture, reflexes of postural stability, such as buttressing against a displacing force, are partially inhibited. These postural characteristics are similar to those of normal rats given haloperidol (5 mg/kg) plus morphine (20 mg/kg) (Pellis et al., 1986).
下丘脑外侧区（LH）损伤会导致大鼠出现感觉忽视、嗜睡和运动不能，而下丘脑腹内侧区（VMH）损伤则会导致大鼠出现感觉反应过度（马歇尔和泰特尔鲍姆，1977年）。同时有LH和VMH大面积损伤的大鼠嗜睡且运动不能，但对触摸反应过度。给LH-VMH损伤的大鼠注射氟哌啶醇（5毫克/千克）后，它们会主动保持一种伸展的姿势，四肢外展并伸展，身体平躺在地上。处于这种姿势时，诸如抵抗移位力的姿势稳定性反射会受到部分抑制。这些姿势特征与注射氟哌啶醇（5毫克/千克）加吗啡（20毫克/千克）的正常大鼠相似（佩利斯等人，1986年）。
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