Zicker S C, Marty G D, Carlson G P, Madigan J E, Smith J M, Goetzman B W
Veterinary Medical Teaching Hospital, University of California, Davis 95616.
J Am Vet Med Assoc. 1990 Jun 15;196(12):2001-5.
Bilateral renal dysplasia and nephron hypoplasia was diagnosed in a Quarter Horse foal with clinical signs of lethargy, convulsions, and diarrhea. Laboratory evaluation revealed anemia, hypoproteinemia, leukopenia, hyponatremia, hypochloremia, and hyposmolality. The foal also had high concentrations of serum creatinine, BUN, and phosphorus. Evaluation of urinary indices revealed a high ratio of urinary gamma-glutamyl-transferase activity to concentration of creatinine, as well as a high fractional clearance ratio of sodium and potassium. Intravenous treatment with saline solution (0.9% NaCl) and antimicrobials provided only temporary resolution of some of the abnormalities. Diagnosis was partly established by histologic evaluation of renal tissue obtained via an ultrasonographically guided biopsy and was confirmed at necropsy. Pathologic changes in the kidney were unique in that the size of the kidneys, along with the appearance and number of glomeruli, were essentially normal despite marked hypoplasia of nephron tubules in the medulla.
一匹 Quarter Horse 马驹被诊断出患有双侧肾发育不全和肾单位发育不全，伴有嗜睡、惊厥和腹泻的临床症状。实验室检查显示贫血、低蛋白血症、白细胞减少、低钠血症、低氯血症和低渗血症。这匹马驹的血清肌酐、血尿素氮和磷浓度也很高。尿液指标评估显示，尿γ-谷氨酰转移酶活性与肌酐浓度之比很高，钠和钾的分数清除率也很高。静脉注射生理盐水（0.9% NaCl）和抗菌药物只能暂时缓解部分异常情况。诊断部分通过超声引导下活检获得的肾组织的组织学评估得以确立，并在尸检时得到证实。肾脏的病理变化独特之处在于，尽管髓质中的肾小管明显发育不全，但肾脏的大小以及肾小球的外观和数量基本正常。
