Department of Obstetrics and Gynecology, Shimane University School of Medicine, Izumo, Japan.
Gynecol Endocrinol. 2013 Jun;29(6):583-7. doi: 10.3109/09513590.2013.788624.
Kisspeptins are known to be the principle regulators of the hypothalamic-pituitary gonadal (HPG) axis. In addition, the role of pituitary adenylate cyclase-activating polypeptide (PACAP) in the regulation of pituitary gonadotropins has been elucidated. We measured plasma concentrations of kisspeptin and PACAP and determined whether the levels of these peptides varied in proportion to circulating gonadotropin levels. Plasma luteinizing hormone (LH) levels were higher in postmenopausal women and in patients with premature ovarian failure (POF) and lower in patients with idiopathic hypogonadotropic hypogonadism (IHH) compared with the LH level in normally menstruating women. Similarly, serum follicle-stimulating hormone levels were higher in postmenopausal women and in patients with POF but lower in pregnant women and patients with IHH compared with normally menstruating women. Plasma levels of kisspeptins were significantly higher in pregnant women compared with normally menstruating women. However, no significant differences were observed in postmenopausal women, patients with POF, and patients with IHH. On the other hand, plasma levels of PACAP were significantly lower in pregnant women, patients with POF, and in IHH patients when compared with normally menstruating women. No significant differences were observed in PACAP concentration between postmenopausal women and in normally menstruating women. Our observations suggest that the serum levels of kisspeptins and PACAP did not correlate with variations in serum gonadotropin levels.
kisspeptins 被认为是下丘脑-垂体-性腺 (HPG) 轴的主要调节因子。此外，垂体腺苷酸环化酶激活肽 (PACAP) 在调节垂体促性腺激素中的作用也已阐明。我们测量了 kisspeptin 和 PACAP 的血浆浓度，并确定这些肽的水平是否与循环促性腺激素水平成比例变化。与正常月经妇女相比，绝经后妇女和卵巢早衰 (POF) 患者的血浆黄体生成素 (LH) 水平较高，而特发性低促性腺激素性性腺功能减退症 (IHH) 患者的 LH 水平较低。同样，血清卵泡刺激素水平在绝经后妇女和 POF 患者中较高，但在孕妇和 IHH 患者中较低，与正常月经妇女相比。与正常月经妇女相比，孕妇的血浆 kisspeptin 水平显著升高。然而，在绝经后妇女、POF 患者和 IHH 患者中未观察到显著差异。另一方面，与正常月经妇女相比，孕妇、POF 患者和 IHH 患者的血浆 PACAP 水平显著降低。绝经后妇女和正常月经妇女之间的 PACAP 浓度无显著差异。我们的观察结果表明，血清 kisspeptin 和 PACAP 水平与血清促性腺激素水平的变化无关。
