Department of Obstetrics and Gynecology, Sapporo Medical University, Sapporo, Hokkaido, Japan.
Gynecol Endocrinol. 2013 Jun;29(6):611-4. doi: 10.3109/09513590.2013.788636.
The purpose of this study was to clarify the risk factors and outcomes of placental polyp. This retrospective study was conducted on 1645 patients delivered or aborted in Sapporo Medical University from 2007 through 2011. Transvaginal color Doppler ultrasonography, hysteroscopy, contrast-enhanced MRI or 3D-CT angiography were performed. There were 1532 deliveries and 113 abortions. Seventy-one (4.3%) were ART-conceived and the remaining 1574 (95.7%) were non-ART pregnancies. Fifteen (0.91%) cases were confirmed as having placental polyp. Nine cases of placental polyp were identified among the 1574 (0.57%) as non-ART-related pregnancies, and 6 were identified among the 71 (8.5%) as ART-related pregnancies. Thus, pregnancies achieved through ART showed 20x greater incidence of complicating placental polyp than pregnancies achieved through without ART (p = 9.02 × 10(-6); odds ratio, 19.59; 95% confidence interval, 5.27-72.84, logistic regression analysis). Evaluation of blood flow within the polyp showed that in five of seven patients with low blood flow, the polyps spontaneously dropped off 79-115 days postpartum. Thus, ART-related pregnancies may be a risk factor of placental polyp, and spontaneous drop-off of the polyp is often observed in cases with low blood flow within the mass.
本研究旨在阐明胎盘息肉的危险因素和结局。该回顾性研究纳入了 2007 年至 2011 年在札幌医科大学分娩或流产的 1645 名患者。对患者进行经阴道彩色多普勒超声、宫腔镜、对比增强 MRI 或 3D-CT 血管造影检查。共有 1532 例分娩和 113 例流产。71 例（4.3%）为辅助生殖技术受孕，其余 1574 例（95.7%）为非辅助生殖技术受孕。71 例（4.5%）中确诊为胎盘息肉 15 例（0.91%）。1574 例（非辅助生殖技术相关妊娠）中发现 9 例胎盘息肉，71 例（辅助生殖技术相关妊娠）中发现 6 例胎盘息肉。因此，辅助生殖技术受孕的胎盘息肉发生率是非辅助生殖技术受孕的 20 倍（p = 9.02 × 10(-6)；比值比，19.59；95%置信区间，5.27-72.84，logistic 回归分析）。对息肉内血流的评估显示，在 7 例低血流患者中，有 5 例息肉在产后 79-115 天自然脱落。因此，辅助生殖技术受孕可能是胎盘息肉的一个危险因素，而在肿块内血流低的情况下，息肉常自然脱落。
