Artico G, Freitas R S, Santos Filho A M, Benard G, Romiti R, Migliari D A
Department of Stomatology, School of Dentistry, University of São Paulo, São Paulo, Brazil.
Oral Dis. 2014 Apr;20(3):e36-41. doi: 10.1111/odi.12120. Epub 2013 May 9.
To determine the frequency of Candida spp., xerostomia, and salivary flow rate (SFR) in three different groups: patients with OLP (OLP group), patients with oral mucosal lesions other than OLP (non-OLP group), and subjects without oral mucosal lesions (control group).
Xerostomia as well as SFR was investigated in the three groups. Samples for isolation of Candida spp. were collected from OLP lesions (38 patients), non-OLP lesions (28 patients), and healthy subjects (32 subjects).
There was no statistically significant difference regarding the frequency of xerostomia and hyposalivation among the three groups (P > 0.05). A higher prevalence for colonization by Candida spp. was found in the healthy subject as compared to that of patients with OLP (P = 0.03) and non-OLP (P = 0.02) groups. Low SFR was not a factor for colonization by Candida spp.
Xerostomia and hyposalivation occur with similar frequency in subjects with and without oral lesions; also, the presence of oral lesions does not increase the susceptibility to colonization by Candida spp. It seems that any study implicating Candida spp. in the malignant transformation of oral lesions should be carried out mostly on a biochemical basis, that is, by testing the capability of Candida spp. to produce carcinogenic enzyme.
确定三组不同人群中念珠菌属、口干症及唾液流速（SFR）的发生频率，这三组人群分别为：口腔扁平苔藓患者（口腔扁平苔藓组）、患有除口腔扁平苔藓以外的口腔黏膜病变的患者（非口腔扁平苔藓组）以及无口腔黏膜病变的受试者（对照组）。
对三组人群进行口干症及唾液流速的调查。从口腔扁平苔藓病变（38例患者）、非口腔扁平苔藓病变（28例患者）及健康受试者（32例）中采集用于分离念珠菌属的样本。
三组人群在口干症及唾液分泌减少的发生频率上无统计学显著差异（P>0.05）。与口腔扁平苔藓患者组（P = 0.03）和非口腔扁平苔藓患者组（P = 0.02）相比，健康受试者中念珠菌属定植的患病率更高。低唾液流速不是念珠菌属定植的一个因素。
有口腔病变和无口腔病变的受试者中，口干症及唾液分泌减少的发生频率相似；此外，口腔病变的存在并不会增加念珠菌属定植的易感性。似乎任何涉及念珠菌属与口腔病变恶变关系的研究都应主要基于生化基础进行，即检测念珠菌属产生致癌酶的能力。
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