Barnes A R
Pharmaceutical Sciences Institute, Aston University, Birmingham, U.K.
J Clin Pharm Ther. 1990 Jun;15(3):187-96. doi: 10.1111/j.1365-2710.1990.tb00374.x.
The chemical stabilities of cefuroxime sodium and metronidazole, when mixed together for intravenous infusion, were studied by high-performance liquid chromatography (HPLC). The critical factor in the stability of the admixture was the degradation of cefuroxime sodium. At 25 degrees C, cefuroxime degraded by first-order kinetics with a rate constant of 7.04 x 10(-2)/day and a t90 (time to reach 90% of the original concentration) of 36 h. At 4 degrees C the rate constant was 5.23 x 10(-3)/day with a t90 of 20 days, however, over the time-scale studied, the kinetics approximated to zero-order at this temperature. The mixture was also stable with respect to metronidazole, nitrite ion and appearance. A 7-day storage life at 4 degrees C can be given to the mixture.
采用高效液相色谱法（HPLC）研究了头孢呋辛钠与甲硝唑混合用于静脉输注时的化学稳定性。混合液稳定性的关键因素是头孢呋辛钠的降解。在25℃时，头孢呋辛按一级动力学降解，速率常数为7.04×10⁻²/天，t90（达到初始浓度90%的时间）为36小时。在4℃时，速率常数为5.23×10⁻³/天，t90为20天，然而，在所研究的时间范围内，该温度下动力学近似为零级。该混合物在甲硝唑、亚硝酸根离子及外观方面也很稳定。该混合液在4℃下可保存7天。
