Faouzi M A, Dine T, Luyckx M, Gressier B, Brunet C, Goudaliez F, Mallevais M L, Cazin M, Cazin J C
Laboratoire de Pharmacologie, Pharmacocinétique et Pharmacie Clinique, Faculté des Sciences Pharmaceutiques et Biologiques, Lille, France.
Pharmazie. 1994 Jun;49(6):425-7.
A rapid isocratic technique was developed for the analysis of three cephalosporins: cefaloridine, cefuroxime and ceftazidime in parenteral solutions using high-performance liquid chromatography (HPLC) with UV detection and C18 column. The availability and compatibility of drugs from solutions infused via plastic infusion bags through plastic administration sets have been examined. No significant drugs loss was observed during the simulated infusions (n = 4) for 1 h using PVC infusion bags and administration sets. No significant difference was found between infusion solutions (5% glucose or 0.9% NaCl). The stability of drugs was also studied in solution in PVC bags after storage at room temperature and at +4 degrees C without protection from light. The results show the stability of drugs during 24 h at room temperature and 7 d storage at +4 degrees C to be satisfactory, irrespective of the infusion solution (5% glucose or 0.9% NaCl).
开发了一种快速等度技术，用于使用配备紫外检测的高效液相色谱（HPLC）和C18柱分析三种头孢菌素：头孢噻啶、头孢呋辛和头孢他啶在注射用溶液中的含量。研究了通过塑料输液袋经塑料给药装置输注的溶液中药物的可用性和相容性。在使用聚氯乙烯（PVC）输液袋和给药装置进行1小时的模拟输注（n = 4）过程中，未观察到明显的药物损失。在输注溶液（5%葡萄糖或0.9%氯化钠）之间未发现显著差异。还研究了药物在PVC袋中的溶液在室温下储存以及在4℃避光储存后的稳定性。结果表明，无论输注溶液是5%葡萄糖还是0.9%氯化钠，药物在室温下24小时以及在4℃储存7天期间的稳定性均令人满意。
