Lab of Nutritional Epidemiology, Department of Nutrition and Food Science, School of Public Health, Tianjin Medical University, 22 Qixiangtai Road, Heping District, 300070 Tianjin, People's Republic of China.
J Gerontol A Biol Sci Med Sci. 2013 Dec;68(12):1482-92. doi: 10.1093/gerona/glt041. Epub 2013 May 8.
Sarcopenia is characterized by the age-related loss of muscle mass and strength. One of the mechanisms of sarcopenia is the loss in the function and number of muscle satellite cells. Royal jelly (RJ) is a health food used worldwide. To obtain better digestion and absorption than RJ, protease-treated RJ (pRJ) has been developed. RJ and pRJ have been suggested to have potential pharmacological benefits such as prolonging the life span and reducing fatigue. Because these effects may improve sarcopenia and the functions of satellite cells, we examined the effects of RJ or pRJ treatment on the skeletal muscles in an animal model using aged mice. In vivo, RJ/pRJ treatment attenuated the decrease in the muscle weight and grip strength and increased the regenerating capacity of injured muscles and the serum insulin-like growth factor-1 levels compared with controls. In vitro, using isolated satellite cells from aged mice, pRJ treatment increased the cell proliferation rate, promoted cell differentiation, and activated Akt intracellular signaling pathway compared with controls. These findings suggest that RJ/pRJ treatment had a beneficial effect on age-related sarcopenia.
肌肉减少症的特征是与年龄相关的肌肉质量和力量丧失。肌肉卫星细胞功能和数量的丧失是肌肉减少症的机制之一。蜂王浆 (RJ) 是一种在全球范围内使用的保健品。为了获得比 RJ 更好的消化和吸收效果，已经开发了蛋白酶处理的 RJ (pRJ)。RJ 和 pRJ 被认为具有潜在的药理益处，例如延长寿命和减轻疲劳。由于这些作用可能改善肌肉减少症和卫星细胞的功能，我们使用老年小鼠动物模型检查了 RJ 或 pRJ 治疗对骨骼肌的影响。在体内，与对照组相比，RJ/pRJ 治疗可减轻肌肉重量和握力的下降，增加受损肌肉的再生能力和血清胰岛素样生长因子-1 水平。在体外，使用来自老年小鼠的分离卫星细胞，与对照组相比，pRJ 处理可提高细胞增殖率、促进细胞分化，并激活 Akt 细胞内信号通路。这些发现表明 RJ/pRJ 治疗对与年龄相关的肌肉减少症有有益的影响。
