The Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, MA, USA.
Cancer Discov. 2013 May;3(5):497-501. doi: 10.1158/2159-8290.CD-13-0059.
Mitochondrial metabolism influences histone and DNA modifications by retrograde signaling and activation of transcriptional programs. Considering the high number of putative sites for acetylation and methylation in chromatin, we propose in this perspective article that epigenetic modifications might impinge on cellular metabolism by affecting the pool of acetyl-CoA and S-adenosylmethionine.
线粒体代谢通过逆行信号转导和转录程序的激活影响组蛋白和 DNA 修饰。考虑到染色质中存在大量假定的乙酰化和甲基化位点，我们在本文中提出，表观遗传修饰可能通过影响乙酰辅酶 A 和 S- 腺苷甲硫氨酸的池来影响细胞代谢。
