[Genetic determinants of generating the motor pattern of rhythmic movements in Drosophila melanogaster].

To investigate molecular and cellular mechanisms of central pattern generators (CPG) functioning, we previously selected candidate genes mutations of which are accompanied with deviations in Drosophila melanogaster motor activity. In this research we tested locomotor parameters in lines with post transcriptional silencing of 12 candidate gene in Drosophila central nervous system. Silencing was provided by synthesis of interfering RNA by means of GAL4/UAS system under control of CNS-specific gene promoters (elav, nrv2, appl, tsh). It was found that RNA interference of most genes are accompanied with changes in one or several locomotor parameters. Pattern of revealed deviations under control of different promotors makes it possible to determine the genes that activity in nervous system is necessary for proper functioning of locomotor CPG.