Unit of Health-Care Epidemiology, Department of Public Health, University of Oxford, Old Road Campus, Oxford, UK.
Epidemiol Infect. 2014 Feb;142(2):371-8. doi: 10.1017/S095026881300099X. Epub 2013 May 10.
We used a database of 248 659 births, with follow-up to subsequent disease, in the Oxford record linkage archive (1979-1999) to study the influence of family, maternal, and perinatal factors on subsequent hospital admission for meningococcal, Haemophilus, and enteroviral meningitis in the children. In this summary, we report key findings that were significant in multivariate analysis. Meningococcal meningitis was significantly associated with maternal smoking [odds ratio (OR) 2·1, 95% confidence interval (CI) 1·2-3·7]. Haemophilus meningitis was associated with having older siblings (e.g. second child compared to first-born, OR 3·3, 95% CI 2·0-5·6). Enteroviral meningitis was associated with low birth weight (OR 2·2, 95% CI 1·3-3·6) and male sex (OR 1·7, 95% CI 1·2-2·3). The mothers of six of the 312 children with enteroviral meningitis had previously had enteroviral meningitis themselves. We concluded that several maternal characteristics influence the risk of these types of meningitis.
我们使用了牛津记录链接档案中的 248659 例出生记录和后续疾病随访数据库（1979-1999 年），以研究家庭、产妇和围产期因素对儿童后续患脑膜炎球菌、流感嗜血杆菌和肠病毒脑膜炎的住院影响。在这个总结中，我们报告了在多变量分析中具有统计学意义的主要发现。脑膜炎球菌性脑膜炎与母亲吸烟显著相关（比值比[OR]2.1，95%置信区间[CI]1.2-3.7）。流感嗜血杆菌性脑膜炎与有年长的兄弟姐妹（例如，与第一个孩子相比，第二个孩子，OR3.3，95%CI2.0-5.6）有关。肠病毒性脑膜炎与低出生体重（OR2.2，95%CI1.3-3.6）和男性（OR1.7，95%CI1.2-2.3）有关。312 例肠病毒性脑膜炎患儿中有 6 例的母亲之前曾患有肠病毒性脑膜炎。我们得出结论，一些产妇特征会影响这些类型脑膜炎的发病风险。
