老年冠心病患者脂蛋白（a）与纤维蛋白原的相关性

[Correlation between lipoprotein(a) and fibrinogen in elderly patients with coronary heart disease].

作者信息

Geng Jie, Chen Shu-tao, Wang Lin

机构信息

Department of Cardiology, Tianjin Chest Hospital, Tianjin, China.

出版信息

Zhonghua Yi Xue Za Zhi. 2013 Feb 5;93(6):436-9.

PMID:23660263

Abstract

OBJECTIVE

To explore the effects of lipoprotein(a) (Lp(a)) and fibrinogen (Fib) in senior patients with coronary heart disease (CHD) and examine the relationship of Lp(a) and Fib.

METHODS

Based upon the results of coronary artery angiography (CAG), 784 subjects aged over 65 years were divided into control (n = 116) group, one-vessel (n = 106) group, two-vessel (n = 120) and three-vessel (n = 442) groups. And the levels of Lp(a) and Fib were measured.

RESULTS

(1) With increasing number of involved branches, the level of Lp(a) gradually rose in male group ((0.22 ± 0.16), (0.28 ± 0.23), (0.32 ± 0.19), (0.34 ± 0.21) g/L; F = 9.22, P < 0.01); (2) whether for males or females, with increasing number of involved branches, the levels of Fib gradually rose in male group ((3.24 ± 0.82), (3.41 ± 0.82), (3.45 ± 0.89), (3.61 ± 0.90) g/L; F = 3.09, P < 0.05) and in female group ((3.58 ± 0.97), (3.69 ± 1.20), (3.77 ± 0.88), (4.09 ± 1.05) g/L; F = 4.34, P < 0.01); (3) the level of Lp(a) had a positive correlation with Fib in male group (r = 0.15, P < 0.01); (4) multi-Logistic regression analysis showed that Lp(a) and Fib were influencing factors of CHD (OR = 0.31, 1.32, both P < 0.05).

CONCLUSION

There are significant correlations between Lp(a), Fib and the severity of CHD in senior male patients.

摘要

目的

探讨脂蛋白(a)（Lp(a)）和纤维蛋白原（Fib）在老年冠心病（CHD）患者中的作用，并研究Lp(a)与Fib之间的关系。

方法

根据冠状动脉造影（CAG）结果，将784例65岁以上受试者分为对照组（n = 116）、单支血管病变组（n = 106）、双支血管病变组（n = 120）和三支血管病变组（n = 442）。并检测Lp(a)和Fib水平。

结果

（1）男性组中，随着病变血管支数增加，Lp(a)水平逐渐升高（(0.22 ± 0.16)、(0.28 ± 0.23)、(0.32 ± 0.19)、(0.34 ± 0.21) g/L；F = 9.22，P < 0.01）；（2）无论男性还是女性，随着病变血管支数增加，男性组Fib水平逐渐升高（(3.24 ± 0.82)、(3.41 ± 0.82)、(3.45 ± 0.89)、(3.61 ± 0.90) g/L；F = 3.09，P < 0.05），女性组Fib水平也逐渐升高（(3.58 ± 0.97)、(3.69 ± 1.20)、(3.77 ± 0.88)、(4.09 ± 1.05) g/L；F = 4.34，P < 0.01）；（3）男性组中Lp(a)水平与Fib呈正相关（r = 0.15，P < 0.01）；（4）多因素Logistic回归分析显示，Lp(a)和Fib是冠心病的影响因素（OR = 0.31，1.32，均P < 0.05）。