Molecular Immunology Unit, Institute of Child Health, University College London, London, United Kingdom.
J Pediatr. 2013 Sep;163(3):908-10. doi: 10.1016/j.jpeds.2013.03.070. Epub 2013 May 6.
Adenovirus causes significant morbidity and mortality in immunocompromised children. We report how an infusion of HLA-matched sibling donor T lymphocytes rapidly eradicated life-threatening, high-level adenoviremia in a child with complete DiGeorge syndrome (22q11.2 deletion) who went on to reconstitute a diverse, donor-derived, postthymic T-cell repertoire.
腺病毒在免疫功能低下的儿童中会引起严重的发病率和死亡率。我们报告了一例 HLA 匹配的同胞供者 T 淋巴细胞输注如何迅速消除危及生命的高水平腺病毒血症，该患儿患有完全性 DiGeorge 综合征（22q11.2 缺失），随后重建了多样化的、供者来源的、胸腺后 T 细胞库。
