Stuart Shani, Donges Bianca, Murrell Melanie, Haupt Larisa M, Lea Rod A, Griffiths Lyn R
School of Medical Science, Genomics Research Centre, Griffith Health Institute, Griffith University, Queensland, Australia.
Neuroreport. 2013 Jul 10;24(10):499-503. doi: 10.1097/WNR.0b013e3283625f55.
Migraine is a debilitating neurovascular disease that is associated with pulsating head pain accompanied by nausea, vomiting, photophobia, phonophobia and sometimes visual sensory disturbances. Because of its role in nitric oxide regulation and interleukin release, apolipoprotein E (APOE) has been suggested to play a role in the migraine pathogenesis pathway. This study evaluated the potential role of three APOE variants in an Australian population and the role that they may play in susceptibility to migraine. The study found no significant association between the tested variants and migraine for any of the APOE variants investigated.
偏头痛是一种使人衰弱的神经血管疾病，与搏动性头痛相关，并伴有恶心、呕吐、畏光、畏声，有时还伴有视觉感觉障碍。由于载脂蛋白E（APOE）在一氧化氮调节和白细胞介素释放中发挥作用，有人提出它在偏头痛发病机制途径中起作用。本研究评估了三种APOE变体在澳大利亚人群中的潜在作用以及它们在偏头痛易感性中可能发挥的作用。研究发现，在所研究的任何APOE变体中，测试变体与偏头痛之间均无显著关联。
