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Toward personalized therapy in AML: in vivo benefit of targeting aberrant epigenetics in MLL-PTD-associated AML.

作者信息

Bernot K M, Siebenaler R F, Whitman S P, Zorko N A, Marcucci G G, Santhanam R, Ahmed E H, Ngangana M, McConnell K K, Nemer J S, Brook D L, Kulp S K, Chen C S, Frankhouser D, Yan P, Bundschuh R, Zhang X, Dorrance A M, Dickerson K E, Jarjoura D, Blum W, Marcucci G, Caligiuri M A

机构信息

1] The Comprehensive Cancer Center and The James Cancer Hospital and Solove Research Institute, Columbus, OH, USA [2] The Ohio State University, Columbus, OH, USA.

出版信息

Leukemia. 2013 Dec;27(12):2379-82. doi: 10.1038/leu.2013.147. Epub 2013 May 10.

DOI:10.1038/leu.2013.147
PMID:23660685
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3864138/
Abstract
摘要

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本文引用的文献

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Increased anti-leukemic activity of decitabine via AR-42-induced upregulation of miR-29b: a novel epigenetic-targeting approach in acute myeloid leukemia.通过 AR-42 诱导 miR-29b 的上调增强地西他滨的抗白血病活性：急性髓细胞白血病的一种新的表观遗传靶向治疗方法。
Leukemia. 2013 Apr;27(4):871-8. doi: 10.1038/leu.2012.342. Epub 2012 Nov 26.
2
Genome-wide methylation profiling in decitabine-treated patients with acute myeloid leukemia.地西他滨治疗急性髓系白血病患者的全基因组甲基化分析。
Blood. 2012 Sep 20;120(12):2466-74. doi: 10.1182/blood-2012-05-429175. Epub 2012 Jul 11.
3
Mll partial tandem duplication and Flt3 internal tandem duplication in a double knock-in mouse recapitulates features of counterpart human acute myeloid leukemias.
一项使用靶向治疗部分串联重复急性髓系白血病的新型方案治疗复发性/难治性成人急性髓系白血病：NCI 8485 期研究结果。
Haematologica. 2018 Jun;103(6):982-987. doi: 10.3324/haematol.2017.186890. Epub 2018 Mar 22.
4
High frequency of additional gene mutations in acute myeloid leukemia with MLL partial tandem duplication: DNMT3A mutation is associated with poor prognosis.伴有MLL部分串联重复的急性髓系白血病中额外基因突变的高频率：DNMT3A突变与预后不良相关。
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Blood. 2013 Nov 28;122(23):3778-83. doi: 10.1182/blood-2013-06-507426. Epub 2013 Oct 1.
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Mll 部分串联重复和 Flt3 内部串联重复在双敲入小鼠中重现了相应人类急性髓系白血病的特征。
Blood. 2012 Aug 2;120(5):1130-6. doi: 10.1182/blood-2012-03-415067. Epub 2012 Jun 6.
4
The novel deacetylase inhibitor AR-42 demonstrates pre-clinical activity in B-cell malignancies in vitro and in vivo.新型去乙酰化酶抑制剂 AR-42 在体外和体内的 B 细胞恶性肿瘤中显示出临床前活性。
PLoS One. 2010 Jun 3;5(6):e10941. doi: 10.1371/journal.pone.0010941.
5
Clinical response and miR-29b predictive significance in older AML patients treated with a 10-day schedule of decitabine.10 天疗程地西他滨治疗老年 AML 患者的临床反应及 miR-29b 的预测意义。
Proc Natl Acad Sci U S A. 2010 Apr 20;107(16):7473-8. doi: 10.1073/pnas.1002650107. Epub 2010 Apr 5.
6
DNA hypermethylation and epigenetic silencing of the tumor suppressor gene, SLC5A8, in acute myeloid leukemia with the MLL partial tandem duplication.伴有MLL部分串联重复的急性髓系白血病中肿瘤抑制基因SLC5A8的DNA高甲基化及表观遗传沉默
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7
Phase I study of decitabine alone or in combination with valproic acid in acute myeloid leukemia.地西他滨单药或联合丙戊酸治疗急性髓系白血病的I期研究。
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