Klinik für Neurochirurgie, Universitätsklinikum Schleswig-Holstein, Campus Kiel, Arnold-Heller-Str. 2, Haus 41, 24105 Kiel, Germany.
J Clin Neurosci. 2013 Aug;20(8):1181-3. doi: 10.1016/j.jocn.2012.09.039. Epub 2013 May 7.
Malignant peripheral nerve sheath tumors (MPNST) are defined as any malignant tumor arising from or differentiating towards the peripheral nerve sheath. Intradural MPNST metastases are very rare. We report, to our knowledge, the first case of leptomeningeal metastasis of a MPNST to the spine and intracranial space. A 56-year-old woman with primary intradural MPNST of the S1 nerve root developed leptomeningeal metastases as well as brain metastases 19 months after diagnosis. The patient had a history of non-Hodgkins lymphoma for which she had received irradiation to the spine 15 years prior to this presentation. She had no stigmata of neurofibromatosis type 1. Patients with MPNST may also develop leptomeningeal metastases as demonstrated in this patient with intradural post-radiation MPNST.
恶性外周神经鞘瘤（MPNST）被定义为源自或向周围神经鞘分化的任何恶性肿瘤。硬脊膜内 MPNST 转移非常罕见。据我们所知，我们报告了首例 MPNST 向脊柱和颅内空间的脑膜转移病例。一名 56 岁女性因 S1 神经根内硬脊膜 MPNST 而发病，在诊断后 19 个月出现脑膜转移和脑转移。该患者有非霍奇金淋巴瘤病史，15 年前曾接受脊柱放疗。她没有 1 型神经纤维瘤病的特征。如本患者硬脊膜内放疗后 MPNST 所示，MPNST 患者也可能发生脑膜转移。
