Curto-Barredo L, Silvestre J F, Giménez-Arnau A M
Servicio de Dermatología, Hospital del Mar-Parc de Salut Mar, Universitat Autónoma, Barcelona, España.
Servicio de Dermatología, Hospital General universitario, Alicante, España.
Actas Dermosifiliogr. 2014 Jun;105(5):469-82. doi: 10.1016/j.ad.2012.12.019. Epub 2013 May 8.
Chronic spontaneous urticaria, also known as chronic idiopathic urticaria or simply chronic urticaria, is a common disorder that has a prevalence in the general population that ranges between 0.5% and 1%. This condition negatively affects the patient's quality of life and has considerable impact on direct and indirect health-related costs. Chronic urticaria is difficult to manage. Nonsedating H1 antihistamines are the first line of therapy, but fewer than 50% of patients experience relief at recommended dosages. Although guidelines call for increasing the dosage when response is inadequate, some patients still do not achieve adequate control of symptoms. New treatment alternatives, with proven efficacy under the standards of evidence-based medical practice, must therefore be developed.
慢性自发性荨麻疹，也称为慢性特发性荨麻疹或简称为慢性荨麻疹，是一种常见疾病，在普通人群中的患病率为0.5%至1%。这种疾病会对患者的生活质量产生负面影响，并对直接和间接的健康相关成本产生相当大的影响。慢性荨麻疹难以治疗。非镇静性H1抗组胺药是一线治疗药物，但在推荐剂量下，只有不到50%的患者症状得到缓解。尽管指南要求在疗效不足时增加剂量，但仍有一些患者无法充分控制症状。因此，必须开发在循证医学实践标准下已证实有效的新治疗方法。
