Program of Genetics & Genome Biology, The Hospital for Sick Children, Toronto, ON M5G 1L7, Canada.
Neuron. 2013 May 8;78(3):405-8. doi: 10.1016/j.neuron.2013.04.034.
In this issue of Neuron, Todd et al. (2013) reveal that noncanonical repeat associated non-AUG (RAN) translation occurs on nonexpanded (CGG)30-50 and premutation (CGG)59-160 repeats, associated with the FMR1 gene, suggesting that the polyglycine and polyalanine products might have natural and pathogenic roles.
在本期《神经元》杂志中，Todd 等人（2013）揭示了非典型重复相关非 AUG（RAN）翻译发生在与 FMR1 基因相关的非扩展（CGG）30-50 和前突变（CGG）59-160 重复序列上，表明多甘氨酸和多丙氨酸产物可能具有自然和致病作用。
