Shaanxi Engineering Center of Bio-Resource Chemistry & Sustainable Utilization, College of Science, Northwest A&F University, Yangling, Shaanxi 712100, China.
Steroids. 2013 Sep;78(9):874-9. doi: 10.1016/j.steroids.2013.04.016. Epub 2013 May 9.
A series of novel derivatives of 21E-benzylidene-pregn-1,4-diene-3,20-dione 7a-g and 21E-benzylidene-4-chloro-pregn-1,4-diene-3,20-dione 8a-g was synthesized from the commercially available progesterone. These title compounds were evaluated for their cytotoxic activity against brine shrimp (Artemia salina) and murine Lewis lung carcinoma cells (LLC). It was found that compounds 7a-g exhibited stronger activities than 8a-g against the brine shrimps, and some of the tested compounds possessed weak inhibition of LLC cells.
一系列新型 21E-苄叉基孕-1,4-二烯-3,20-二酮 7a-g 和 21E-苄叉基-4-氯孕-1,4-二烯-3,20-二酮 8a-g 的衍生物从市售的黄体酮合成。评价了这些标题化合物对卤虫（盐水虾）和小鼠刘易斯肺癌细胞（LLC）的细胞毒性活性。发现化合物 7a-g 对卤虫的活性强于 8a-g，一些测试化合物对 LLC 细胞具有较弱的抑制作用。
