Research Department of Chemistry, VHNSN College, Virudhunagar 626 001, India.
Spectrochim Acta A Mol Biomol Spectrosc. 2013 Aug;112:198-205. doi: 10.1016/j.saa.2013.04.054. Epub 2013 Apr 22.
Five new Mn(II), Co(II), Ni(II), Cu(II) and Zn(II) mixed ligand complexes have been synthesized using a Schiff base precursor (obtained by the condensation of N-(4-aminophenyl)acetamide and 4-chlorobenzaldehyde) as main ligand and 1,10-phenanthroline as co-ligand. They have been characterized by microanalytical data, IR, UV-Vis, magnetic moment values, conductivity and electrochemical measurements. The spectral data reveal that all the complexes exhibit octahedral geometry. The high electrical conductance of the complexes supports their electrolytic nature. The monomeric nature of the complexes has been assessed from their magnetic susceptibility values. These complexes are better antimicrobial active agents than the free ligands. DNA (CT) binding properties of these complexes have been explored by UV-Vis., viscosity measurements, cyclic voltammetry, and differential pulse voltammetry measurements. The oxidative cleavage activity of the complexes has been studied using supercoiled pUC19 DNA by gel electrophoresis. The experimental results show that the complexes are good intercalators.
五种新的 Mn(II)、Co(II)、Ni(II)、Cu(II) 和 Zn(II) 混合配体配合物已通过使用席夫碱前体（由 N-(4-氨基苯基)乙酰胺和 4-氯苯甲醛缩合而成）作为主要配体和 1,10-菲啰啉作为辅助配体合成。它们通过微量分析数据、IR、UV-Vis、磁矩值、电导率和电化学测量进行了表征。光谱数据表明，所有配合物都呈现八面体几何形状。配合物的高电导率支持其具有电解性质。从它们的磁化率值评估了配合物的单体性质。这些配合物作为抗菌剂比游离配体的效果更好。通过紫外可见光谱、粘度测量、循环伏安法和差分脉冲伏安法研究了这些配合物与 DNA（CT）的结合特性。通过凝胶电泳研究了配合物的氧化断裂活性。实验结果表明，这些配合物是良好的嵌入剂。
