基于病毒学、免疫学、临床和/或依从性标准预测 HIV 耐药性：喀麦隆 Stratall ANRS 12110/ESTHER 试验。
Prediction of HIV drug resistance based on virologic, immunologic, clinical, and/or adherence criteria in the Stratall ANRS 12110/ESTHER trial in Cameroon.
机构信息
Institut de Recherche pour le Développement (IRD), University Montpellier 1, UMI 233 TransVIHMI, Montpellier, France.
出版信息
Clin Infect Dis. 2013 Aug;57(4):604-7. doi: 10.1093/cid/cit323. Epub 2013 May 10.
PMID:23667264
Abstract
Our study in Cameroonian rural district hospitals showed that the immunologic and clinical failure criteria had poor performance to identify human immunodeficiency virus drug resistance in a timely manner. Switching to second-line antiretroviral therapy after 2 consecutive viral loads ≥5000 copies/mL, as recommended by the World Health Organization, appeared to be the most appropriate strategy.
摘要
我们在喀麦隆农村地区医院的研究表明，免疫和临床失败标准在及时识别人类免疫缺陷病毒耐药方面表现不佳。按照世界卫生组织的建议，在连续两次病毒载量≥5000 拷贝/毫升后，转换为二线抗逆转录病毒治疗似乎是最合适的策略。
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