催乳素对大鼠肝脏和肾脏DNA甲基化的影响。
Effect of prolactin on DNA methylation in the liver and kidney of rat.
作者信息
Reddy P M, Reddy P R
机构信息
School of Life Sciences, University of Hyderabad, India.
出版信息
Mol Cell Biochem. 1990 Jun 1;95(1):43-7. doi: 10.1007/BF00219528.
Prolactin is an important growth modulatory hormone in fetal and adult tissues. It stimulates DNA synthesis and enzymatic markers of the G1 phase of cell cycle in rat liver and other tissues. In this study the effects of prolactin on 5-methyl cytosine content in liver and kidney of rats was studied using HPLC. Prolactin treatment caused hypomethylation of DNA in the liver and kidney of immature rats at 48 h after treatment and the effect remained even at 72 h. Prolactin also caused hypomethylation of DNA in the kidney and liver of adult rats at 48 h after treatment. These results indicate that prolactin probably regulates DNA methylation in the liver and kidney of immature and adult rats.
催乳素是胎儿和成年组织中一种重要的生长调节激素。它能刺激大鼠肝脏和其他组织中细胞周期G1期的DNA合成和酶标记物。在本研究中，使用高效液相色谱法研究了催乳素对大鼠肝脏和肾脏中5-甲基胞嘧啶含量的影响。催乳素处理导致未成熟大鼠在处理后48小时肝脏和肾脏中的DNA发生低甲基化，并且即使在72小时时该作用仍然存在。催乳素还导致成年大鼠在处理后48小时肾脏和肝脏中的DNA发生低甲基化。这些结果表明，催乳素可能调节未成熟和成年大鼠肝脏和肾脏中的DNA甲基化。
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