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Lack of DNA single-strand breaks in rat liver cells exposed to 4-acetylaminofluorene, in vivo and in vitro.

作者信息

Nizard C, Decloître F

机构信息

Institut de Recherches Scientifiques sur le Cancer, Villejuif, France.

出版信息

Mutat Res. 1990 Jul;244(3):245-50. doi: 10.1016/0165-7992(90)90136-8.

DOI:10.1016/0165-7992(90)90136-8
PMID:2366818
Abstract

The induction of primary DNA damage by the non-carcinogen 4-AAF was reinvestigated in liver cells by comparison with the carcinogen 2-AAF. DNA alkaline elution showed the appearance of single-strand breaks in total liver DNA of rats 4 h after gavage with 200 mg/kg of 4-AAF. The decrease in hepatocyte viability and yield observed in these livers after collagenase perfusion indicated a cytotoxic effect of 4-AAF treatment. Viable hepatocytes isolated from 4-AAF-treated rats as well as hepatocytes from normal rats treated with 4-AAF in vitro did not present DNA single-strand breaks.

摘要

相似文献

1
Lack of DNA single-strand breaks in rat liver cells exposed to 4-acetylaminofluorene, in vivo and in vitro.
Mutat Res. 1990 Jul;244(3):245-50. doi: 10.1016/0165-7992(90)90136-8.
2
Association between DNA strand breaks and specific DNA adducts in murine hepatocytes following in vivo and in vitro exposure to N-hydroxy-2-acetylaminofluorene and N-acetoxy-2-acetylaminofluorene.在体内和体外暴露于N-羟基-2-乙酰氨基芴和N-乙酰氧基-2-乙酰氨基芴后，小鼠肝细胞中DNA链断裂与特定DNA加合物之间的关联。
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3
Induction of single-strand breaks and interstrand cross-links in liver DNA after the administration of 2-acetylaminofluorene and trans-4-acetylaminostilbene to rats.给大鼠注射2-乙酰氨基芴和反式-4-乙酰氨基芪后肝脏DNA中单链断裂和链间交联的诱导情况。
J Biochem Toxicol. 1987 Fall-Winter;2:271-9. doi: 10.1002/jbt.2570020311.
4
Sex differences in DNA damage produced by the carcinogen 2-acetylaminofluorene in cultured human hepatocytes compared to rat liver and cultured rat hepatocytes.与大鼠肝和培养的大鼠肝细胞相比，致癌物 2-乙酰氨基芴在培养的人肝细胞中产生的 DNA 损伤存在性别差异。
Arch Toxicol. 2016 Feb;90(2):427-32. doi: 10.1007/s00204-014-1415-3. Epub 2014 Dec 16.
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The genotoxicity of aromatic amines in primary hepatocytes isolated from C57BL/6 and DBA/2 mice.从C57BL/6和DBA/2小鼠分离出的原代肝细胞中芳香胺的遗传毒性。
Carcinogenesis. 1984 Jun;5(6):797-804. doi: 10.1093/carcin/5.6.797.
6
Impaired nuclear accumulation and shortened phosphorylation of ERK after growth factor stimulation in cultured hepatocytes from rats exposed to 2-acetylaminofluorene.
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7
The carcinogen 2-acetylaminofluorene inhibits activation and nuclear accumulation of cyclin-dependent kinase 2 in growth-induced rat liver.致癌物2-乙酰氨基芴抑制生长诱导的大鼠肝脏中细胞周期蛋白依赖性激酶2的激活和核积累。
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8
Changes in levels of ADP-ribose polymers in rat liver during 2-acetylaminofluorene-induced hepatocarcinogenesis.2-乙酰氨基芴诱导大鼠肝癌发生过程中肝脏中ADP-核糖聚合物水平的变化
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Cytoskeleton modifications induced by phenobarbital, 2-acetylaminofluorene and 4-acetylaminofluorene in normal and initiated/selected hepatocytes: relation with the "resistant" phenotype.苯巴比妥、2-乙酰氨基芴和4-乙酰氨基芴在正常及起始/选择的肝细胞中诱导的细胞骨架修饰：与“抗性”表型的关系
Cell Biol Toxicol. 1993 Jan-Mar;9(1):61-76. doi: 10.1007/BF00755140.
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Unscheduled DNA synthesis of rat hepatocytes in monolayer culture.单层培养的大鼠肝细胞的非程序性DNA合成。
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引用本文的文献

1
Cytoskeleton modifications induced by phenobarbital, 2-acetylaminofluorene and 4-acetylaminofluorene in normal and initiated/selected hepatocytes: relation with the "resistant" phenotype.苯巴比妥、2-乙酰氨基芴和4-乙酰氨基芴在正常及起始/选择的肝细胞中诱导的细胞骨架修饰：与“抗性”表型的关系
Cell Biol Toxicol. 1993 Jan-Mar;9(1):61-76. doi: 10.1007/BF00755140.