Kaplan J A, Bush G L, Lecky J H, Ominsky A J, Wollman H
Anesthesiology. 1975 May;42(5):550-8. doi: 10.1097/00000542-197505000-00008.
The cardiovascular effects of acute metabolic alkalosis (NaHCO3) in normal male volunteers anesthetized with halothane were measured. Pure metabolic alkalosis was studied by maintaning the end-tidal carbon dioxide tension at 40 torr. In each subject, cardiac index increased and total peripheral resistance decreased after each dose of NaHCO3. The increased cardiac index was associated with increased central blood volume, left ventricular minute work index, stroke index, and heart rate. Systolic time intervals showed increased myocardial performance. NaHCO3 administered to volunteers whose hearts were depressed by halothane appeared to cause peripheral vasodilation, volume expansion, and myocardial stimulation. The authors conclude that NaHCO3 administered during halothane anesthesia decreases total peripheral resistance and may lead to severe hypotension.
对用氟烷麻醉的正常男性志愿者进行了急性代谢性碱中毒（碳酸氢钠）心血管效应的测定。通过将呼气末二氧化碳分压维持在40托来研究单纯性代谢性碱中毒。在每个受试者中，每次给予碳酸氢钠后心脏指数增加，总外周阻力降低。心脏指数增加与中心血容量、左心室每分钟作功指数、每搏指数和心率增加有关。收缩期时间间期显示心肌功能增强。对心脏被氟烷抑制的志愿者给予碳酸氢钠似乎会引起外周血管舒张、血容量增加和心肌兴奋。作者得出结论，在氟烷麻醉期间给予碳酸氢钠会降低总外周阻力，并可能导致严重低血压。
