Mathieu A, Di Padua D, Kahan B D, Mills J
Anesthesiology. 1975 May;42(5):612-6. doi: 10.1097/00000542-197505000-00024.
Trifluoroacetate, a common metabolite of halothane, fluroxene, and enflurane, conjugated to guinea-pig albumin elicits specific serum antibody in guinea pigs. Two classes of antibodies were found: hemolytic, gamma-2, and anaphylactic, gamma-1. Repeated injections of the antigen, trifluoroacetyl-guinea pig albumin, often led to disappearance of circulating antibodies.
