Meyer A, Jacobsen P, Magnussen H
Krankenhaus Grosshansdorf, Zentrum für Pneumologie und Thoraxchirurgie.
Pneumologie. 1990 Feb;44 Suppl 1:236-7.
We made the observations that in patients with severe bronchial asthma, the inhalative dose of beta-2 sympathomimetics that was required for optimal bronchial dilation revealed a large inter-individual scatter. In 21 patients, the inhalation of a maximum of 10 metered doses of salbutamol at intervals of five minutes each, led to a mean (SD) increase in the FEV 1.0 from 1.3 (0.6) 1 to 1.8 (0.7) 1. The maximum increase in the FEV 1.0 was achieved in 10 patients following the inhalation of 1 to 3 metered doses, and in 11 patients after 4 to 10 such doses. The individual requirement for inhaleable beta-2 agonists should therefore be taken into account when planning treatment.
我们观察到，在重度支气管哮喘患者中，实现最佳支气管扩张所需的β-2拟交感神经药吸入剂量存在很大的个体差异。在21例患者中，每隔5分钟吸入最多10次定量沙丁胺醇，FEV 1.0平均（标准差）从1.3（0.6）升增加到1.8（0.7）升。10例患者在吸入1至3次定量剂量后FEV 1.0达到最大增幅，11例患者在吸入4至10次定量剂量后达到最大增幅。因此，在制定治疗方案时应考虑个体对吸入性β-2激动剂的需求。
