通过斯米尔诺夫重排反应构建无过渡金属的串联过程合成吡啶并[3,2-f][1,4]噻嗪-二酮。
A transition metal-free tandem process to pyridazinopyrido[3,2-f][1,4]thiazepine-diones via Smiles rearrangement.
机构信息
School of Chemistry and Chemical Engineering, Shandong University, Jinan, 250100, PR China.
出版信息
Org Biomol Chem. 2013 Jun 28;11(24):4102-8. doi: 10.1039/c3ob40719e.
PMID:23674063
Abstract
A transition metal-free methodology for the synthesis of pyridazinopyrido[3,2-f][1,4]thiazepine-diones was studied. The construction of this tricyclic system went through a one-pot coupling/Smiles rearrangement/cyclization process. The high yields of pure products were obtained through simple recrystallization.
摘要
研究了一种无过渡金属的方法，用于合成吡啶并[3,2-f][1,4]噻嗪-二酮。这个三环系统的构建经历了一锅偶联/Smiles 重排/环化过程。通过简单的重结晶得到了高产率的纯产物。
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