Musch E, Lütjohann D, Peter M G, Schwabe H K
Medizinische Universitätsklinik Bonn.
Pneumologie. 1990 Feb;44 Suppl 1:490-2.
A specific direct method for determining the isoniazid derivative isonicotinoyl-hydrazine sodium glucuronide (INHG-Na) with the aid of high-pressure liquid chromatography has been developed, which permits the analysis of this derivative of isoniazid in addition to isoniazid itself and acetylisoniazid in the plasma of patients. In initial pharmacokinetic applications of the method, it has been shown that plasma INHG-Na is a stable substance that liberates only negligible concentrations of INH.
已开发出一种借助高压液相色谱法测定异烟肼衍生物异烟酰肼葡糖醛酸钠（INHG-Na）的特定直接方法，该方法除了可分析患者血浆中的异烟肼本身和乙酰异烟肼外，还能分析异烟肼的这种衍生物。在该方法最初的药代动力学应用中，已表明血浆INHG-Na是一种稳定物质，仅释放出可忽略不计浓度的异烟肼（INH）。
