白塞病中的抗中性粒细胞胞浆抗体
Anti-Neutrophil Cytoplasmic Antibody in Behçet's Disease.
作者信息
Duzgun Nursen, Sahin Mehmet, Ayaslioglu Ergin
机构信息
Department of Clinical Immunology and Rheumatology, Ankara University School of Medicine Ankara, Turkey;
出版信息
Int J Biomed Sci. 2006 Feb;2(1):49-52.
Anti neutrophil cytoplasmic antibody (ANCA) is strongly associated with some vasculitic disorders. Behçet's disease (BD) is a systemic vasculitis of unknown etiology. In this study, ANCA was found to be positive in 8 out of 66 patients (10.2%) with BD by combination testing consisting of immunofluorescence and ELISA [one patient showed an atypical pattern by indirect immunofloresence techique, 6 patients were reactive to bacterial-permeability increasing protein (BPI) and one patient was reactive to Cathepsin G in ELISA]. There were no vascular manifestations such as veneous or arterial thrombosis and arterial aneurysms in ANCA-positive patients with BD. The results suggest that ANCA may be found in a minority of BD as those in previous published studies.
抗中性粒细胞胞浆抗体（ANCA）与某些血管炎疾病密切相关。白塞病（BD）是一种病因不明的系统性血管炎。在本研究中，通过免疫荧光和酶联免疫吸附测定（ELISA）联合检测发现，66例BD患者中有8例（10.2%）ANCA呈阳性[1例患者通过间接免疫荧光技术显示非典型模式，6例患者对细菌通透性增加蛋白（BPI）反应阳性，1例患者在ELISA中对组织蛋白酶G反应阳性]。BD患者ANCA阳性者未出现静脉或动脉血栓形成及动脉瘤等血管表现。结果表明，与先前发表的研究一样，少数BD患者中可能会发现ANCA。
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