Lee Seung-Pyo, Youn Seock-Won, Kim Hyo-Soo
National Research Laboratory for Cardiac Stem Cell, Seoul National University College of Medicine, Seoul, Korea.
Int J Biomed Sci. 2007 Mar;3(1):1-8.
Integrin-linked kinase (ILK) is an intracellular molecule that binds to the cytoplasmic domain of β1 and β3-integrin. It has been previously demonstrated in various epithelial cell lines to mediate the 'outside-in' signals into the cells and to control the survival of these cells by controlling the phosphorylation of various downstream proteins, such as protein kinase B/Akt (PKB/Akt). We now present in this review the important role of ILK in the vascular system with particular emphasis on its role in endothelial cells (ECs). The results presented here demonstrate that ILK is essential for the proper function, structure and survival of ECs and finally, for the process of neovascularization.
整合素连接激酶（ILK）是一种细胞内分子，可与β1和β3整合素的细胞质结构域结合。先前已在多种上皮细胞系中证实，它能将“由外向内”信号介导进入细胞，并通过控制各种下游蛋白（如蛋白激酶B/Akt，PKB/Akt）的磷酸化来控制这些细胞的存活。在本综述中，我们阐述了ILK在血管系统中的重要作用，尤其着重介绍其在内皮细胞（ECs）中的作用。此处呈现的结果表明，ILK对于ECs的正常功能、结构和存活至关重要，最终对于新血管形成过程也至关重要。
