Kim C K, Palestro C J, Solomon R W, Molinari D S, Lee S O, Goldsmith S J
Andre Meyer Department of Physics and Nuclear Medicine, Mount Sinai Medical Center, Mount Sinai School of Medicine, New York, NY 10029.
Radiology. 1990 Aug;176(2):553-6. doi: 10.1148/radiology.176.2.2367674.
The authors assessed the influence of cholecystokinin (CCK), administered before cholescintigraphy, on the biliary-to-bowel transit time (BBTT) of technetium-99m disofenin. Fourteen healthy volunteers underwent two separate cholescintigraphic studies with and without CCK treatment. BBTT was less than 1 hour in all 14 studies of subjects not treated with CCK. In 14 subjects treated with CCK, there was no tracer activity in the bowel up to 2 hours in seven (50%) (P = .006). Eighty-three cholescintigrams obtained in patients with suspected acute cholecystitis were also retrospectively analyzed. In 53 of 83 patients in whom the gallbladder was visualized within 1 hour, significantly delayed BBTT was found in 14 of 29 (48%) who received CCK, compared with the BBTT in one of 24 patients (4%) who did not receive CCK (P less than .001). In the 30 patients in whom the gallbladder was never visualized (n = 28) or was visualized after 1 hour (n = 2), BBTT was less than 30 minutes, regardless of whether patients were treated with CCK. Results show that CCK treatment causes significantly delayed BBTT in many cases, and this finding should not be interpreted as abnormal.
作者评估了在胆囊闪烁扫描术前给予胆囊收缩素（CCK）对锝-99m 地索芬宁从胆汁到肠道转运时间（BBTT）的影响。14 名健康志愿者分别接受了两次胆囊闪烁扫描研究，一次使用 CCK 治疗，另一次不使用。在未接受 CCK 治疗的所有 14 项受试者研究中，BBTT 均小于 1 小时。在接受 CCK 治疗的 14 名受试者中，7 名（50%）在长达 2 小时内肠道内无示踪剂活性（P = 0.006）。还对 83 例疑似急性胆囊炎患者的胆囊闪烁扫描图像进行了回顾性分析。在 83 例胆囊在 1 小时内显影的患者中，29 例接受 CCK 治疗的患者中有 14 例（48%）BBTT 明显延迟，而 24 例未接受 CCK 治疗的患者中有 1 例（4%）出现这种情况（P 小于 0.001）。在 30 例胆囊从未显影（n = 28）或在 1 小时后显影（n = 2）的患者中，无论是否接受 CCK 治疗，BBTT 均小于 30 分钟。结果表明，CCK 治疗在许多情况下会导致 BBTT 明显延迟，且这一发现不应被解释为异常。
