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[HIV感染患者的内脏利什曼病]

[Visceral leishmaniasis in patient with HIV infection].

作者信息

Olea Pilar, Pinilla Jorge

机构信息

Hospital de Enfermedades Infecciosas Dr. Lucio Córdova, Chile.

出版信息

Rev Chilena Infectol. 2013 Apr;30(2):216-20. doi: 10.4067/S0716-10182013000200013.

Abstract

Leishmaniasis is a parasitic disease caused by the protozoa of the genus Leishmania transmitted by sandfly bites. It causes subclinical infection and diverse clinical manifestations with cutaneous, mucosal or visceral involvement. The last one, called visceral leishmaniasis, is usually fatal without treatment and in VIH patients with deep immunosuppression, has been recognized as an opportunistic infection with a high degree of difficulty in diagnosis and treatment. We present the case of a patient with HIV infection and visceral leishmaniasis. The clinical presentation was a prolonged febril syndrome with hepatosplenomegaly, lymphadenopathy and pancytopenia. The differential diagnosis was made with lymphoma and other opportunistic infections, as mycobacteriosis. The bone marrow aspirate reveled parasite amastigotes. The patient received treatment with amphotericin B deoxycholate for 14 days and 2 months after he relapsed. Then he was treated with the same drug for 21 days and after that he has been in prophylaxis for 29 months with good outcome, without any other relapse.

摘要

利什曼病是一种由利什曼原虫属的原生动物引起的寄生虫病,通过白蛉叮咬传播。它可导致亚临床感染以及涉及皮肤、黏膜或内脏的多种临床表现。最后一种,即内脏利什曼病,若不治疗通常会致命,而在免疫严重抑制的艾滋病患者中,已被确认为一种诊断和治疗难度极大的机会性感染。我们报告一例艾滋病合并内脏利什曼病患者的病例。临床表现为伴有肝脾肿大、淋巴结病和全血细胞减少的长期发热综合征。鉴别诊断考虑了淋巴瘤和其他机会性感染,如分枝杆菌病。骨髓穿刺发现了寄生虫无鞭毛体。患者接受了去氧胆酸两性霉素B治疗14天,复发后又治疗了2个月。然后再次使用同一药物治疗21天,之后进行了29个月的预防治疗,效果良好,未再复发。

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