Pollak Felipe, Vásquez Tatiana
Departamento de Nutrición, Diabetes y Metabolismo, Facultad de Medicina, Pontificia Universidad Católica de Chile, Chile.
Rev Med Chil. 2012 Nov;140(11):1476-81. doi: 10.4067/S0034-98872012001100015.
Latent Autoimmune Diabetes in Adults (LADA) is the term used to describe adults who have a slowly progressive form of diabetes mellitus (DM) of autoimmune etiology, but that may be treated initially without insulin. Although it shares some immunological and genetic aspects with type 1 DM, it affects an age group that is typically affected by type 2 DM. Therefore, it could be considered an intermediate type. Diagnosis is based on clinical and laboratory criteria: age of onset, initial response to oral hypoglycemic agents and the presence of specific antibodies for diabetes. Although the definitive treatment is insulin, glitazones may be useful in early stages of the disease. Currently, its management represents a challenge for the physician, including specialists, and it is a form of DM to keep in mind.
成人隐匿性自身免疫性糖尿病（LADA）是用于描述患有自身免疫病因的缓慢进展型糖尿病（DM）的成年人的术语，但最初可能无需胰岛素治疗。尽管它与1型糖尿病有一些免疫和遗传方面的共性，但它影响的是通常受2型糖尿病影响的年龄组。因此，它可被视为一种中间类型。诊断基于临床和实验室标准：发病年龄、对口服降糖药的初始反应以及糖尿病特异性抗体的存在。尽管最终治疗是胰岛素，但格列酮类药物在疾病早期可能有用。目前，其管理对包括专科医生在内的医生来说是一项挑战，并且它是一种需要牢记的糖尿病类型。
