University Hospital, Institute of Forensic Medicine, Stiftsplatz 12, 53111, Bonn, Germany.
Drug Test Anal. 2013 Sep-Oct;5(9-10):741-4. doi: 10.1002/dta.1490. Epub 2013 May 15.
A nurse administered the neuromuscular blocking agent succinylcholine (SUX) to at least one patient and gave first aid in the therapy of unexpected respiratory depression. SUX is regarded as an undetectable and thus perfect poison due to its short half-life and degradation to the endogenous compounds choline and succinic acid. However, SUX and especially its metabolite succinylmonocholine (SMC) were found in plasma and urine a few hours after administration by means of high performance liquid chromatography-tandem mass spectrometry (HPLC-MS/MS). Compared to clinical studies, the window of detection was sufficient to gain definite proof; in other cases no samples were collected. The nurse enjoyed high reputation with the doctors. According to the court she wanted to present herself spectacularly as the first and decisive rescuer to demonstrate her special abilities and capacities, perhaps to receive a better job in the hospital. Considering the actual case, the hero syndrome is not limited to fire-fighters.
一名护士向至少一名患者施用了神经肌肉阻滞剂琥珀酰胆碱（SUX），并在治疗意外呼吸抑制时进行了急救。由于其半衰期短且降解为内源性化合物胆碱和琥珀酸，SUX 被认为是一种无法检测到的、因此是完美的毒药。然而，通过高效液相色谱-串联质谱法（HPLC-MS/MS），在给药数小时后在血浆和尿液中发现了 SUX 及其代谢物琥珀酰单胆碱（SMC）。与临床研究相比，检测窗口足以提供明确的证据；在其他情况下，未采集样本。该护士与医生享有很高的声誉。根据法庭的说法，她想以惊人的方式展示自己，作为第一个决定性的救援者，以展示她的特殊能力，也许是为了在医院获得更好的工作。考虑到实际情况，英雄综合征不仅限于消防员。
