疑似高凝状态患者急性缺血性卒中情况下的凝血因子VIII
Factor VIII in the setting of acute ischemic stroke among patients with suspected hypercoagulable state.
作者信息
Chang Tiffany R, Albright Karen C, Boehme Amelia K, Dorsey Adrianne, Sartor E Alton, Kruse-Jarres Rebecca, Leissinger Cindy, Martin-Schild Sheryl
机构信息
1Stroke Program, Department of Neurology, Tulane University School of Medicine, New Orleans, LA, USA.
出版信息
Clin Appl Thromb Hemost. 2014 Mar;20(2):124-8. doi: 10.1177/1076029613488936. Epub 2013 May 14.
BACKGROUND
Elevation of factor VIII is associated with higher risk of large vessel arterial occlusions including stroke.
METHODS
Factor VIII levels were examined in consecutive patients with acute ischemic stroke (AIS) presenting to a single center between July 2008 and May 2012. Factor VIII levels exceeding the laboratory reference range were considered elevated (>150%).
RESULTS
Factor VIII level was elevated in 72.4% (84 of 116) of the patients. Elevated factor VIII level was more frequent in blacks, diabetics, and patients who were anemic. Patients with elevated factor VIII had higher median baseline National Institute of Health Stroke Scale (NIHSS; 5 vs 2, P = .0295) and twice the frequency of neuroworsening (21.4% vs 9.4%), but discharge NIHSS and modified Rankin Scale were similar in the groups.
CONCLUSIONS
High factor VIII level was found in the majority of tested patients with AIS. Several baseline differences were found between patients with normal and high factor VIII levels, but no differences were identified in outcome.
背景
凝血因子VIII升高与包括中风在内的大血管动脉闭塞风险较高相关。
方法
对2008年7月至2012年5月期间在单一中心就诊的连续急性缺血性中风（AIS）患者的凝血因子VIII水平进行检测。凝血因子VIII水平超过实验室参考范围被视为升高（>150%）。
结果
72.4%（116例中的84例）患者的凝血因子VIII水平升高。黑人、糖尿病患者和贫血患者中凝血因子VIII水平升高更为常见。凝血因子VIII水平升高的患者基线美国国立卫生研究院卒中量表（NIHSS）中位数更高（5分对2分，P = 0.0295），神经功能恶化频率是两倍（21.4%对9.4%），但两组出院时的NIHSS和改良Rankin量表相似。
结论
在大多数接受检测的AIS患者中发现凝血因子VIII水平较高。凝血因子VIII水平正常和升高的患者之间存在一些基线差异，但在结局方面未发现差异。
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