The Royal Veterinary College, London, UK.
J Vet Intern Med. 2013 Jul-Aug;27(4):904-12. doi: 10.1111/jvim.12107. Epub 2013 May 16.
Boxer dogs are reported to be predisposed to arrhythmogenic right ventricular cardiomyopathy (ARVC), but the natural history has not been well characterized and inconsistent diagnostic criteria have been applied to identify affected dogs. Echocardiographic examination findings are unremarkable in many affected Boxer dogs, and in these dogs, 24-hour ambulatory ECG (Holter) monitoring often is used for diagnostic and prognostic purposes, despite limited information available relating Holter findings to outcome.
HYPOTHESIS/OBJECTIVES: Boxers with complex ventricular arrhythmias at initial presentation will have shorter survival times. The objective was to investigate the prognostic value of Holter monitoring in Boxer dogs.
One hundred and twenty-two Boxer dogs seen at 3 university referral hospitals.
Retrospective study. Survival times were obtained for Boxer dogs evaluated by echocardiography and a 24-hour Holter ECG. Kaplan-Meier survival analysis was used to estimate the median survival time and Cox proportional hazards analysis was used to identify variables independently associated with cardiac mortality.
Outcome data were obtained for 122/163 dogs meeting the inclusion criteria. Of the 70 dogs that had died, 45 were considered to have suffered cardiac-related deaths. Median survival was significantly longer in dogs with a left ventricular systolic diameter (LVIDs) ≤ 35 mm compared with those with LVIDs > 35 mm (P < .001). Multivariable analysis in dogs with LVIDs ≤ 35 mm showed that the presence of ventricular tachycardia, age >4.5 years, and male sex were independent predictors of cardiac mortality.
Holter monitoring in Boxer dogs provides valuable prognostic information.
拳师犬被报道易患致心律失常性右室心肌病（ARVC），但尚未很好地描述其自然病史，且应用不一致的诊断标准来识别受影响的犬。许多受影响的拳师犬的超声心动图检查结果无明显异常，在这些犬中，尽管与 Holter 结果相关的信息有限，但为了诊断和预后目的，通常会进行 24 小时动态心电图（Holter）监测。
假说/目的：初次就诊时出现复杂室性心律失常的拳师犬的生存时间较短。本研究旨在探讨 Holter 监测在拳师犬中的预后价值。
在 3 所大学转诊医院就诊的 122 只拳师犬。
回顾性研究。通过超声心动图和 24 小时 Holter ECG 评估的拳师犬获得生存时间。使用 Kaplan-Meier 生存分析估计中位生存时间，并使用 Cox 比例风险分析识别与心脏死亡率独立相关的变量。
符合纳入标准的 163 只犬中，有 122 只获得了结果数据。在 70 只死亡的犬中，45 只被认为死于与心脏相关的疾病。左心室收缩直径（LVIDs）≤35mm 的犬的中位生存时间明显长于 LVIDs＞35mm 的犬（P＜0.001）。在 LVIDs≤35mm 的犬中进行多变量分析显示，室性心动过速、年龄＞4.5 岁和雄性是心脏死亡率的独立预测因素。
拳师犬的 Holter 监测提供了有价值的预后信息。
