Orfali Raquel Leão, Shimizu Marta M, Takaoka Roberto, Zaniboni Mariana C, Ishizaki Aline S, Costa Anderson A, Tiba Ana Paula L, Sato Maria Notomi, Aoki Valéria
Department of Dermatology, Medical School, Universidade de São Paulo USP, São Paulo, SP, Brazil.
Rev Assoc Med Bras (1992). 2013 May-Jun;59(3):270-5. doi: 10.1016/j.ramb.2012.12.004. Epub 2013 May 13.
Atopic dermatitis (AD) is a chronic inflammatory disease causing intense pruritus, and with typical clinical features. There are few epidemiological studies concerning AD in adults, as well as little information about its prognostic. The aim of this study was to evaluate the clinical and epidemiological course of adults with AD.
80 patients aged above 18 years (mean age=29 years) were selected (30 males and 50 females) and interviewed about hospitalization, systemic corticoid usage, age of AD onset, and personal and/or familial history of atopy. Disease severity was evaluated through the Scoring Atopic Dermatitis (SCORAD) tool. Laboratory examination included IgE serum levels and eosinophil blood count.
71 out of 80 patients referred association with respiratory symptoms (18 had asthma, 17 had rhinitis, and 36 had both conditions); nine out of 80 patients denied any respiratory disease. AD patients were divided in mild (n=25), moderate (n=30), and severe (n=25); 56% had one or more hospitalizations due to AD. A positive association was found between IgE serum levels, eosinophil blood count, and disease severity.
Adult AD represents a clinical challenge that needs to be better characterized, since it can be misdiagnosed and interferes with the patient's social and personal life. The association of skin and respiratory atopic disease is frequent, and laboratory parameters such as circulating IgE levels and eosinophil blood count may be helpful to assess disease severity.
特应性皮炎（AD）是一种导致剧烈瘙痒的慢性炎症性疾病，具有典型的临床特征。关于成人AD的流行病学研究较少，其预后相关信息也不多。本研究的目的是评估成人AD的临床和流行病学病程。
选取80例年龄在18岁以上（平均年龄=29岁）的患者（30例男性和50例女性），询问其住院情况、全身使用皮质类固醇情况、AD发病年龄以及个人和/或家族特应性病史。通过特应性皮炎评分（SCORAD）工具评估疾病严重程度。实验室检查包括血清IgE水平和嗜酸性粒细胞计数。
80例患者中有71例提及有呼吸道症状（18例患有哮喘，17例患有鼻炎，36例两者都有）；80例患者中有9例否认有任何呼吸道疾病。AD患者分为轻度（n=25）、中度（n=30）和重度（n=25）；56%的患者因AD有过一次或多次住院。血清IgE水平、嗜酸性粒细胞计数与疾病严重程度之间存在正相关。
成人AD是一项需要更好地加以特征描述的临床挑战，因为它可能被误诊并干扰患者的社会和个人生活。皮肤和呼吸道特应性疾病常相关，循环IgE水平和嗜酸性粒细胞计数等实验室参数可能有助于评估疾病严重程度。
