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基于人群的出生队列中注意缺陷多动障碍儿童遗尿和遗粪的发生率。

Incidence of enuresis and encopresis among children with attention-deficit/hyperactivity disorder in a population-based birth cohort.

机构信息

Behavioral Medicine and Clinical Psychology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio 45229-3039, USA.

出版信息

Acad Pediatr. 2013 Jul-Aug;13(4):322-7. doi: 10.1016/j.acap.2013.02.008. Epub 2013 Mar 1.

Abstract

OBJECTIVE

This study reports the incidence of enuresis and encopresis among children with attention-deficit/hyperactivity disorder (ADHD) versus those without ADHD.

METHODS

Subjects included 358 children (74.5% boys) with research-identified ADHD from a 1976 to 1982 population-based birth cohort (n = 5718) and 729 (75.2% boys) non-ADHD control subjects from the same birth cohort, matched by gender and age. All subjects were retrospectively followed from birth until a diagnosis of enuresis or encopresis was made or last follow-up before 18 years of age. The complete medical record for each subject was reviewed to obtain information on age of initial diagnosis of an elimination disorder, frequency and duration of symptoms, and identification of exclusionary criteria specified by DSM-IV, with confirmation of the diagnosis by expert consensus.

RESULTS

Children with ADHD were 2.1 (95% confidence interval [CI], 1.3-3.4; P = .002) times more likely to meet DSM-IV criteria for enuresis than non-ADHD controls; they were 1.8 (95% CI, 1.2-2.7; P = .006) times more likely to do so than non-ADHD controls when less stringent criteria for a diagnosis of enuresis were employed. Though not significant, children with ADHD were 1.8 (95% CI, 0.7-4.6; P = .23) times more likely to meet criteria for encopresis than non-ADHD controls. The relative risk was 2.0 (95% CI, 1.0-4.1; P = .05) when a less stringent definition for encopresis was utilized.

CONCLUSIONS

Children with ADHD are more likely than their peers without ADHD to develop enuresis with a similar trend for encopresis.

摘要

目的

本研究报告了伴有注意缺陷多动障碍(ADHD)与不伴 ADHD 的儿童遗尿和遗粪的发病率。

方法

研究对象包括来自 1976 年至 1982 年基于人群的出生队列的 358 名(74.5%为男性)经研究确定的 ADHD 儿童(n=5718)和来自同一出生队列的 729 名(75.2%为男性)非 ADHD 对照组儿童,通过性别和年龄进行匹配。所有受试者均从出生开始进行回顾性随访,直到出现遗尿或遗粪诊断,或在 18 岁之前进行最后一次随访。对每位受试者的完整病历进行审查,以获取首次诊断为排泄障碍的年龄、症状的频率和持续时间,以及 DSM-IV 规定的排除标准信息,并通过专家共识确认诊断。

结果

与非 ADHD 对照组相比,患有 ADHD 的儿童出现 DSM-IV 遗尿诊断标准的可能性高 2.1 倍(95%置信区间 [CI],1.3-3.4;P=.002);当采用更宽松的遗尿诊断标准时,其患病可能性高 1.8 倍(95%CI,1.2-2.7;P=.006)。虽然不显著,但与非 ADHD 对照组相比,患有 ADHD 的儿童出现 DSM-IV 遗粪诊断标准的可能性高 1.8 倍(95%CI,0.7-4.6;P=0.23)。当采用更宽松的遗粪定义时,相对风险为 2.0(95%CI,1.0-4.1;P=0.05)。

结论

与无 ADHD 的同龄人相比,患有 ADHD 的儿童更有可能发生遗尿症,且发生遗粪症的趋势相似。

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