Blasco-Fontecilla Hilario, Li Chao, Vizcaino Miguel, Fernández-Fernández Roberto, Royuela Ana, Bella-Fernández Marcos
Instituto de Investigación, Transferencia e Innovación, Ciencias de la Saludy Escuela de Doctorado, Universidad Internacional de La Rioja, 26006 Logroño, Spain.
Center of Biomedical Network Research on Mental Health (CIBERSAM), Carlos III Institute of Health, 28029 Madrid, Spain.
J Clin Med. 2024 Apr 19;13(8):2397. doi: 10.3390/jcm13082397.
To enhance the early detection of Attention Deficit/Hyperactivity Disorder (ADHD) and Autism Spectrum Disorder (ASD) by leveraging clinical variables collected at child and adolescent mental health services (CAMHS). This study included children diagnosed with ADHD and/or ASD ( = 857). Three logistic regression models were developed to predict the presence of ADHD, its subtypes, and ASD. The analysis began with univariate logistic regression, followed by a multicollinearity diagnostic. A backward logistic regression selection strategy was then employed to retain variables with < 0.05. Ethical approval was obtained from the local ethics committee. The models' internal validity was evaluated based on their calibration and discriminative abilities. The study produced models that are well-calibrated and validated for predicting ADHD (incorporating variables such as physical activity, history of bone fractures, and admissions to pediatric/psychiatric services) and ASD (including disability, gender, special education needs, and Axis V diagnoses, among others). Clinical variables can play a significant role in enhancing the early identification of ADHD and ASD.
通过利用在儿童和青少年心理健康服务(CAMHS)中收集的临床变量,加强对注意力缺陷/多动障碍(ADHD)和自闭症谱系障碍(ASD)的早期检测。本研究纳入了被诊断为ADHD和/或ASD的儿童( = 857)。开发了三个逻辑回归模型来预测ADHD的存在、其亚型以及ASD。分析首先进行单变量逻辑回归,随后进行多重共线性诊断。然后采用向后逻辑回归选择策略保留p < 0.05的变量。获得了当地伦理委员会的伦理批准。基于模型的校准和判别能力评估了模型的内部有效性。该研究生成了经过良好校准和验证的模型,用于预测ADHD(纳入了诸如身体活动、骨折史以及儿科/精神科服务入院情况等变量)和ASD(包括残疾、性别、特殊教育需求以及轴V诊断等)。临床变量在加强ADHD和ASD的早期识别方面可以发挥重要作用。