Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD 20852, USA.
Ann Oncol. 2013 Aug;24(8):2073-9. doi: 10.1093/annonc/mdt175. Epub 2013 May 16.
Some patients diagnosed with early-stage lung cancer and treated according to standard care survive for only a short period of time, while others survive for years for reasons that are not well understood. Associations between markers of inflammation and survival from lung cancer have been observed.
Here, we investigate whether circulating levels of 77 inflammatory markers are associated with long versus short survival in stage I and II lung cancer. Patients who had survived either <79 weeks (~1.5 years) (short survivors, SS) or >156 weeks (3 years) (long survivors, LS) were selected from a retrospective population-based study. Logistic regression was used to calculate adjusted odds ratios (ORs) and corresponding 95% confidence intervals (CIs). The false discovery rate was calculated to adjust for multiple testing.
A total of 157 LS and 84 SS were included in this analysis. Thirteen markers had adjusted OR on the order of 2- to 5-fold when comparing the upper and lower quartiles with regard to the odds of short survival versus long. Chemokine CCL15 [chemokine (C-C motif) ligand 15] was the most significant marker associated with increased odds of short survival (ORs = 4.93; 95% CI 1.90-12.8; q-value: 0.042). Smoking and chronic obstructive pulmonary disease were not associated with marker levels.
Our results provide some evidence that deregulation of inflammatory responses may play a role in the survival of early-stage lung cancer. These findings will require confirmation in future studies.
一些被诊断为早期肺癌并按照标准治疗的患者只能存活很短的时间，而另一些患者则存活了数年，其原因尚不清楚。已经观察到炎症标志物与肺癌生存之间的关联。
在这里，我们研究了循环中 77 种炎症标志物的水平是否与 I 期和 II 期肺癌的长短生存有关。从一项回顾性基于人群的研究中选择了存活时间<79 周（~1.5 年）（短存活者，SS）或>156 周（3 年）（长存活者，LS）的患者。使用逻辑回归计算调整后的比值比（OR）和相应的 95％置信区间（CI）。使用错误发现率（FDR）来调整多重检验。
共纳入了 157 名 LS 和 84 名 SS 进行了此项分析。当比较短生存与长生存的四分位数之间的可能性时，有 13 个标志物的调整 OR 为 2 到 5 倍。趋化因子 CCL15（趋化因子（C-C 基序）配体 15）是与短生存几率增加相关的最显著标志物（ORs=4.93；95%CI 1.90-12.8；q 值：0.042）。吸烟和慢性阻塞性肺疾病与标志物水平无关。
我们的结果提供了一些证据，表明炎症反应的失调可能在早期肺癌的生存中起作用。这些发现需要在未来的研究中得到证实。
