Akagi Hiroyuki, Iwata Munetaka, Ichinohe Tomu, Amimoto Hirokazu, Hayashi Yuuta, Kannno Nobuo, Ochi Hiroki, Fujita Yukihiro, Harada Yasuji, Tagawa Masahiro, Hara Yasushi
1Division of Veterinary Surgery, Department of Veterinary Science, Faculty of Veterinary Medicine, Nippon Veterinary and Life Science University, Musashino, Tokyo, Japan.
J Biomater Appl. 2014 Feb;28(6):954-62. doi: 10.1177/0885328213487754. Epub 2013 May 15.
Hydroxyapatite (HA)/poly-l-lactide(PLLA) composite biomaterials are available for orthopedic applications, but bioresorption and cell-mediated inflammation in bone cortex are unknown. We conducted an 84-month follow-up study with Beagle dogs that were subjected to implants with either PLLA (left femur) or HA/PLLA (right femur). Histological and radiographic analysis showed that HA/PLLA screws induced significant increases in HA content from 36 months onward and complete burr hole closure at 60 months, whereas PLLA screws did not. Moreover, PLLA screws induced more severe fibrous tissue and histiocyte infiltration. HA/PLLA screws promote earlier burr hole replacement and have superior biocompatibility compared to PLLA screws.
羟基磷灰石（HA）/聚左旋乳酸（PLLA）复合生物材料可用于骨科应用，但在骨皮质中的生物吸收和细胞介导的炎症尚不清楚。我们对一组比格犬进行了为期84个月的随访研究，这些比格犬的左股骨植入PLLA，右股骨植入HA/PLLA。组织学和影像学分析表明，HA/PLLA螺钉从36个月起HA含量显著增加，60个月时骨钻孔完全闭合，而PLLA螺钉则没有。此外，PLLA螺钉引起更严重的纤维组织和组织细胞浸润。与PLLA螺钉相比，HA/PLLA螺钉能促进骨钻孔的早期替代，并且具有更好的生物相容性。
