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1
Response of lymphocyte guanyl cyclase to propranolol, noradrenaline, thymoxamine, and acetylcholine in extrinsic bronchial asthma.外源性支气管哮喘中淋巴细胞鸟苷酸环化酶对普萘洛尔、去甲肾上腺素、胸腺氧胺和乙酰胆碱的反应
Br Med J. 1975 May 17;2(5967):357-9. doi: 10.1136/bmj.2.5967.357.
2
Relationships between responsiveness of the bronchi to acetylcholine and cyclic AMP response of lymphocytes to beta 1- and beta 2-adrenergic receptor stimulation in patients with asthma.哮喘患者支气管对乙酰胆碱的反应性与淋巴细胞对β1和β2肾上腺素能受体刺激的环磷酸腺苷反应之间的关系。
Allergy. 1983 Jan;38(1):37-42. doi: 10.1111/j.1398-9995.1983.tb00854.x.
3
Atropine, sodium cromoglycate, and thymoxamine in PGF2 alpha-induced bronchoconstriction in extrinsic asthma.阿托品、色甘酸钠和百里胺在前列腺素F2α诱发的外源性哮喘支气管收缩中的作用
Br Med J. 1975 May 17;2(5967):360-2. doi: 10.1136/bmj.2.5967.360.
4
Response of leucocyte adenyl cyclase to isoprenaline and effect of alpha-blocking drugs in extrinsic bronchial asthma.白细胞腺苷酸环化酶对异丙肾上腺素的反应及α-阻滞剂在外源性支气管哮喘中的作用
Br Med J. 1974 Jan 19;1(5898):90-3. doi: 10.1136/bmj.1.5898.90.
5
[Changed equilibrium between the sympathetic-adenyl cyclase-cyclic AMP-PGE system and the cholinergic-guanyl cyclase-cyclic GMP-PGF2 alpha system as a pathogenetic mechanism of bronchial asthma].[交感神经-腺苷酸环化酶-环磷酸腺苷-前列腺素E系统与胆碱能-鸟苷酸环化酶-环磷酸鸟苷-前列腺素F2α系统之间平衡的改变作为支气管哮喘的发病机制]
G Clin Med. 1980 Jun;61(6):444-8.
6
Effect of alpha receptor blocking drug, thymoxamine, on allergen induced bronchoconstriction in extrinsic asthma.α受体阻断药百里胺对外源性哮喘中变应原诱发的支气管收缩的作用。
Clin Allergy. 1975 Sep;5(3):311-6. doi: 10.1111/j.1365-2222.1975.tb01868.x.
7
Alterations in cyclic adenosine monophosphate metabolism in human bronchial asthma. I. Leukocyte responsiveness to -adrenergic agents.人类支气管哮喘中环磷酸腺苷代谢的改变。I. 白细胞对β-肾上腺素能药物的反应性。
J Clin Invest. 1973 Jan;52(1):48-59. doi: 10.1172/JCI107173.
8
Guanosine cyclic 3',5'-monophosphate and guanylate cyclase activity in guinea pig lung: effects of acetylcholine and cholinesterase inhibitors.豚鼠肺组织中环磷酸鸟苷及鸟苷酸环化酶活性：乙酰胆碱及胆碱酯酶抑制剂的作用
Mol Pharmacol. 1974 Jan;10(1):155-61.
9
Pathogenesis of asthma. Neurophysiology and pharmacology of bronchospasm.哮喘的发病机制。支气管痉挛的神经生理学与药理学。
Chest. 1982 Feb;81(2):224-9. doi: 10.1378/chest.81.2.224.
10
Effect of beta adrenergic blockage on bronchial sensitivity to inhaled acetylcholine in normal subjects.β肾上腺素能阻滞对正常受试者支气管对吸入乙酰胆碱敏感性的影响。
J Allergy Clin Immunol. 1975 Mar;55(3):164-9. doi: 10.1016/0091-6749(75)90012-3.

引用本文的文献

1
Electrophysiology of T lymphocyte cholinergic receptors.T淋巴细胞胆碱能受体的电生理学
Proc Natl Acad Sci U S A. 1980 Jul;77(7):4317-21. doi: 10.1073/pnas.77.7.4317.
2
The in vitro effects of propranolol and atenolol on neutrophil motility and post-phagocytic metabolic activity.普萘洛尔和阿替洛尔对中性粒细胞运动性及吞噬后代谢活性的体外作用。
Immunology. 1979 May;37(1):15-24.

本文引用的文献

1
A COMPARISON OF THE EFFECTS OF ISOPROTERENOL IN THE NORMAL AND ASTHMATIC SUBJECT. A PRELIMINARY REPORT.异丙肾上腺素对正常人和哮喘患者作用的比较。初步报告。
Am Rev Respir Dis. 1963 Nov;88:636-43. doi: 10.1164/arrd.1963.88.5.636.
2
Adenyl cyclase as an adrenergic receptor.作为肾上腺素能受体的腺苷酸环化酶。
Ann N Y Acad Sci. 1967 Feb 10;139(3):703-23. doi: 10.1111/j.1749-6632.1967.tb41239.x.
3
Metabolic response to epinephrine in bronchial asthma.支气管哮喘中对肾上腺素的代谢反应。
J Allergy. 1968 Nov;42(5):288-99. doi: 10.1016/0021-8707(68)90022-1.
4
Effects of epinephrine on asthmatic children. Effects of epinephrine on blood glucose, pulmonary function, and heart rate of children with asthma of varying severity.肾上腺素对哮喘儿童的影响。肾上腺素对不同严重程度哮喘儿童血糖、肺功能和心率的影响。
J Allergy. 1967 Dec;40(6):337-48. doi: 10.1016/0021-8707(67)90023-8.
5
Effects of catecholamines and adrenergic-blocking agents on plasma and urinary cyclic nucleotides in man.儿茶酚胺和肾上腺素能阻滞剂对人体血浆及尿中环核苷酸的影响。
J Clin Invest. 1972 Aug;51(8):2124-9. doi: 10.1172/JCI107019.
6
Guanosine 3':5'-cyclic monophosphate and the action of insulin and acetylcholine.3':5'-环磷酸鸟苷以及胰岛素与乙酰胆碱的作用
Proc Natl Acad Sci U S A. 1973 Aug;70(8):2443-7. doi: 10.1073/pnas.70.8.2443.
7
Cyclic GMP response in vivo to cholinergic stimulation of gastric mucosa.体内胃黏膜胆碱能刺激引起的环磷酸鸟苷反应。
Nature. 1974 Mar 15;248(445):238-9. doi: 10.1038/248238a0.
8
The modulating influence of cyclic nucleotides upon lymphocyte-mediated cytotoxicity.环核苷酸对淋巴细胞介导的细胞毒性的调节作用。
J Exp Med. 1973 Aug 1;138(2):381-93. doi: 10.1084/jem.138.2.381.
9
The formation and metabolism of cyclic GMP.环磷酸鸟苷的形成与代谢
Ann N Y Acad Sci. 1971 Dec 30;185:27-35. doi: 10.1111/j.1749-6632.1971.tb45232.x.
10
Stimulation of adenosine 3',5'-monophosphate hydrolysis by guanosine 3',5'-monophosphate.鸟苷 3',5'-单磷酸对腺苷 3',5'-单磷酸水解的刺激作用。
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外源性支气管哮喘中淋巴细胞鸟苷酸环化酶对普萘洛尔、去甲肾上腺素、胸腺氧胺和乙酰胆碱的反应

Response of lymphocyte guanyl cyclase to propranolol, noradrenaline, thymoxamine, and acetylcholine in extrinsic bronchial asthma.

作者信息

Haddock A M, Patel K R, Alston W C, Kerr J W

出版信息

Br Med J. 1975 May 17;2(5967):357-9. doi: 10.1136/bmj.2.5967.357.

DOI:10.1136/bmj.2.5967.357
PMID:236809
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1673146/
Abstract

The lymphocyte guanyl cyclase response to alpha-agonists was studied in 10 normal people and 12 patients with bronchial asthma. In the normal subjects alpha-adrenergic stimulation with noradrenaline plus propranolol and cholinergic stimulation with acetylcholine evoked significant increases in cyclic guanosine monophosphate formation. In addition the alpha-receptor blocking drug thymoxamine produced a significant stimulation of this enzyme system, and the effects of thymoxamine and acetylcholine were additive. This suggests that receptors for cholinergic and alpha-adrenergic agents are independent. In contrast, lymphocyte guanyl cyclase activity did not show a significant response to these agents in patients with acute asthma. In asthmatic patients in remission the responses were partially restored. The significance of these results for control of bronchomotor tone and the relation of guanyl cyclase activity to cyclic adenosine monophosphate in normal subjects and patients with asthma is discussed.

摘要

对10名正常人和12名支气管哮喘患者的淋巴细胞鸟苷酸环化酶对α-激动剂的反应进行了研究。在正常受试者中，去甲肾上腺素加普萘洛尔的α-肾上腺素能刺激以及乙酰胆碱的胆碱能刺激均引起环磷酸鸟苷生成的显著增加。此外，α-受体阻断药百里胺对该酶系统有显著刺激作用，且百里胺和乙酰胆碱的作用是相加的。这表明胆碱能和α-肾上腺素能药物的受体是独立的。相比之下，急性哮喘患者的淋巴细胞鸟苷酸环化酶活性对这些药物未表现出显著反应。在缓解期的哮喘患者中，反应部分恢复。讨论了这些结果对支气管运动张力控制的意义以及正常人和哮喘患者中鸟苷酸环化酶活性与环磷酸腺苷的关系。