外源性支气管哮喘中淋巴细胞鸟苷酸环化酶对普萘洛尔、去甲肾上腺素、胸腺氧胺和乙酰胆碱的反应
Response of lymphocyte guanyl cyclase to propranolol, noradrenaline, thymoxamine, and acetylcholine in extrinsic bronchial asthma.
作者信息
Haddock A M, Patel K R, Alston W C, Kerr J W
出版信息
Br Med J. 1975 May 17;2(5967):357-9. doi: 10.1136/bmj.2.5967.357.
The lymphocyte guanyl cyclase response to alpha-agonists was studied in 10 normal people and 12 patients with bronchial asthma. In the normal subjects alpha-adrenergic stimulation with noradrenaline plus propranolol and cholinergic stimulation with acetylcholine evoked significant increases in cyclic guanosine monophosphate formation. In addition the alpha-receptor blocking drug thymoxamine produced a significant stimulation of this enzyme system, and the effects of thymoxamine and acetylcholine were additive. This suggests that receptors for cholinergic and alpha-adrenergic agents are independent. In contrast, lymphocyte guanyl cyclase activity did not show a significant response to these agents in patients with acute asthma. In asthmatic patients in remission the responses were partially restored. The significance of these results for control of bronchomotor tone and the relation of guanyl cyclase activity to cyclic adenosine monophosphate in normal subjects and patients with asthma is discussed.
对10名正常人和12名支气管哮喘患者的淋巴细胞鸟苷酸环化酶对α-激动剂的反应进行了研究。在正常受试者中，去甲肾上腺素加普萘洛尔的α-肾上腺素能刺激以及乙酰胆碱的胆碱能刺激均引起环磷酸鸟苷生成的显著增加。此外，α-受体阻断药百里胺对该酶系统有显著刺激作用，且百里胺和乙酰胆碱的作用是相加的。这表明胆碱能和α-肾上腺素能药物的受体是独立的。相比之下，急性哮喘患者的淋巴细胞鸟苷酸环化酶活性对这些药物未表现出显著反应。在缓解期的哮喘患者中，反应部分恢复。讨论了这些结果对支气管运动张力控制的意义以及正常人和哮喘患者中鸟苷酸环化酶活性与环磷酸腺苷的关系。
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