普萘洛尔和阿替洛尔对中性粒细胞运动性及吞噬后代谢活性的体外作用。
The in vitro effects of propranolol and atenolol on neutrophil motility and post-phagocytic metabolic activity.
作者信息
Anderson R, van Rensburg A J
出版信息
Immunology. 1979 May;37(1):15-24.
Propranolol at concentrations of 1 x 10(-6) to 1 x 10(-4) M consistently increased neutrophil motility as measured in Boyden chambers. The effects were not due solely to stimulation of random migration and chemokinesis but also of directional motility. Propranolol, over a similar concentration range, caused inhibition of post-phagocytic cell metabolic activity (hexose monophosphate shunt, nitro-blue tetrazolium reduction and protein iodination) without any detectable effect on the ingestion rate of Candida albicans. Atenolol had no effect on any of these neutrophil functions. Both drugs were without effect on glycolysis and intracellular cyclic AMP levels. Propranolol however, at concentrations which stimulated cell motility, caused increased intracellular cyclic GMP levels. It is suggested that propranolol may stimulate neutrophil motility by promoting increased intracellular cyclic GMP levels or by decreasing neutrophil superoxide production.
在博伊登小室中检测发现，浓度为1×10⁻⁶至1×10⁻⁴M的普萘洛尔持续增加中性粒细胞的运动能力。其作用并非仅仅归因于对随机迁移和化学增活作用的刺激，还包括定向运动。在相似的浓度范围内，普萘洛尔会抑制吞噬后细胞的代谢活性（己糖磷酸支路、硝基蓝四氮唑还原及蛋白质碘化），但对白色念珠菌的摄取率没有任何可检测到的影响。阿替洛尔对这些中性粒细胞功能均无影响。两种药物对糖酵解和细胞内环磷酸腺苷水平均无作用。然而，普萘洛尔在刺激细胞运动的浓度下，会导致细胞内环磷酸鸟苷水平升高。提示普萘洛尔可能通过促进细胞内环磷酸鸟苷水平升高或减少中性粒细胞超氧化物生成来刺激中性粒细胞运动。
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